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RPA3 Antibodies
AND RPA3 ELISA kits, RPA3 Proteins
Many biological assays use antibodies to detect RPA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPA3 antibodies...
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RPA3 Overview
Facts about Replication protein A 14 kDa subunit.
Replication protein A 14 kDa subunit (RPA3)
Included in the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different complexes and proteins involved in DNA metabolism.
Thereby, it plays a vital role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | RPA3 |
| Uniprot: | P35244 |
| Entrez: | 6119 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
REPA3Replication factor A protein 3; replication protein A 14 kDa subunit; replication protein A3 (14kD); replication protein A3, 14kDa; RF-A protein 3; RP-A p14; RPA14
Molecular Weight
Mass (kDA):
13.569 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p21.3 |
| Sequence: | 7; NC_000007.14 (7636518..7718607, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Endocrine Gland Neoplasms
- Neoplasm Metastasis
- Malignant Squamous Cell Neoplasm
- Hereditary Diseases
- Skin Neoplasms
- Lung Neoplasms
- Metastatic Malignant Neoplasm To The Lymph Node
- Melanoma
- Xeroderma Pigmentosum
- Atrophy
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
Interacting Proteins
- RAD52
- RPA1
- RPA2
Pathways
- Dna Replication
- Dna Repair
- Cell Cycle
- Telomere Maintenance
- Mitosis
- Cell Cycle Arrest
- S Phase
- Single-stranded Dna Binding
- Meiosis
- Cell Proliferation
- Localization
- Anaphase
PTMs
- Phosphorylation
Research Areas
- Cancer
- Checkpoint signaling
- Core ESC-Like Genes
- DNA Double Strand Break Repair
- DNA Repair
- Nucleotide Excision Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPA3
bosterbio.com/bosterbio-gene-info-cards/RPA3
References
PMID: 8454588 by Umbricht C.B., et al. Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A.
PMID: 7697716 by Aboussekhra A., et al. Mammalian DNA nucleotide excision repair reconstituted with purified protein components.