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ROCK1 Antibodies
AND ROCK1 ELISA kits, ROCK1 Proteins
Many biological assays use antibodies to detect ROCK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ROCK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ROCK1 antibodies...
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ROCK1 Infographic by Boster Bio
All ROCK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00722
100 μl
Cat # M00722
100 μl
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$380
Cat # A00722-3
100ul
Cat # A00722-3
100ul
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00722-4
100 μg/vial
Cat # A00722-4
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00722-5
100 µg/vial
Cat # A00722-5
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00722-6
100 µg/vial
Cat # A00722-6
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M00722-1
100 µl/vial
Cat # M00722-1
100 µl/vial
ROCK1 Overview
Facts about Rho-associated protein kinase 1.
Rho-associated protein kinase 1 (ROCK1)
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A.
Phosphorylates FHOD1 and acts synergistically with it to market SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress.
Gene Information
| Human | |
|---|---|
| Gene Name: | ROCK1 |
| Uniprot: | Q13464 |
| Entrez: | 6093 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; MGC131603; MGC43611; p160 ROCK-1; p160ROCK; p160-ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho kinase; rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; ROCK1; ROK beta
Molecular Weight
Mass (kDA):
158.175 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.1 |
| Sequence: | 18; NC_000018.10 (20946906..21111813, complement) |
Tissue Specificity
Detected in blood platelets.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi mem
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Cell Invasion
- Neoplasm Metastasis
- Hypertensive Disease
- Neoplasm Invasiveness
- Fibrosis
- Diabetes Mellitus
- Inflammation
- Cardiovascular Diseases
- Carcinoma
- Pathologic Vasoconstriction
Interacting Proteins
- CFAP206
- FAM124A
- FRMD5
- LMO2
- MAGEB4
- MYBPH
- POLR3C
- RHOA
- TSG101
Pathways
- Cell Migration
- Pathogenesis
- Cell Adhesion
- Cell Motility
- Localization
- Cell Proliferation
- Cell Death
- Cell Cycle
- Chemotaxis
- Angiogenesis
- Rna Interference
- Regeneration
- Muscle Contraction
PTMs
- Phosphorylation
- Cleavage
- Methylation
Research Areas
- Apoptosis
- Breast Cancer
- Cancer
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ROCK1
bosterbio.com/bosterbio-gene-info-cards/ROCK1
References
PMID: 8617235 by Ishizaki T., et al. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
PMID: 9722579 by Van Eyk J.E., et al. Different molecular mechanisms for Rho family GTPase-dependent, Ca2+- independent contraction of smooth muscle.