Nuclear receptor ROR-alpha (RORA)

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing one core motif half-site 5'-AGGTCA-3' preceded by a brief A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism.

Considered to possess intrinsic transcriptional activity, have some organic ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory areas to regulate their transcriptional expression, depending on the tissue, time and promoter contexts.