RNF212 Antibodies

AND RNF212 ELISA kits, RNF212 Proteins

Many biological assays use antibodies to detect RNF212, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF212 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF212 antibodies...

We validate the specificity of these antibodies to RNF212 by testing them on tissues known to express RNF212 positively and negatively. Browse below to find the RNF212 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF212 Infographic by Boster Bio

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Anti-RNF212 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A11605-2
100 µg/vial

RNF212 Overview

Facts about Probable E3 SUMO-protein ligase RNF212.

RNF212 3D structure. Source: alphafold

Probable E3 SUMO-protein ligase RNF212 (RNF212)

SUMO E3 ligase that serves as a regulator of crossing-over during meiosis: needed to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11.

May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination websites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist part with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).

Gene Information

Human
Gene Name:	RNF212
Uniprot:	Q495C1
Entrez:	285498

Family

Belongs to:

No superfamily

Alternative Names

FLJ38841; FLJ42587; hypothetical protein LOC285498; MGC120227; MGC120228; ring finger protein 212; ZHP3

Molecular Weight

Mass (kDA):
33.365 kDA

Genomic Context


Human

Location:	4p16.3
Sequence:	4; NC_000004.12 (1056248..1113794, complement)

Subcellular Localizations

Nucleus. Chromosome. Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).

Diseases

Autistic Disorder

Pathways

Meiosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF212

References

PMID: 18239089 by Kong A., et al. Sequence variants in the RNF212 gene associate with genome-wide recombination rate.