Rnf146 Antibodies

AND Rnf146 ELISA kits, Rnf146 Proteins

Many biological assays use antibodies to detect Rnf146, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rnf146 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rnf146 antibodies...

We validate the specificity of these antibodies to Rnf146 by testing them on tissues known to express Rnf146 positively and negatively. Browse below to find the Rnf146 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Rnf146 Infographic by Boster Bio

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RNF146 (NM_030963) Human Over-expression Lysate

Human

$628
Cat # LS081847
100 µg

Rnf146 Overview

Facts about E3 ubiquitin-protein ligase RNF146.

E3 ubiquitin-protein ligase RNF146 (Rnf146)

May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 important parts of the beta-catenin destruction complex.

Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination (By similarity).

Gene Information

Mouse
Gene Name:	Rnf146
Uniprot:	Q9CZW6
Entrez:	68031

Family

Belongs to:

No superfamily

Alternative Names

dactylidin; dJ351K20.1; DKFZp434O1427; ring finger protein 146,2610509H23Rik; RP3-351K20.1

Molecular Weight

Mass (kDA):
38.934 kDA

Genomic Context


Mouse

Location:	10\|10 A4
Sequence:	10;

Tissue Specificity

Expressed at relatively high levels in the brain. Also present in spleen, heart, kidney, testis and liver. In the brain, expressed in the cerebellum, hippocampus, striatum, cortex, frontal cortex and, at lowest levels, in olfactory bulb (at protein level). Predominantly expressed in neurons.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Cell Transformation, Neoplastic
Congenital Abnormality
Neoplasms
Neurodegenerative Disorders
Inflammation

Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Cherubism

Pathways

Cell Death
Dna Repair
Fatty Acid Oxidation
Pathogenesis
Tissue Homeostasis

PTMs

Phosphorylation
Oxidation

Ribosylation
Ubiquitination

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rnf146

References

PMID: 15813938 by von Rotz R.C., et al. The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.

PMID: 21602803 by Andrabi S.A., et al. Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.