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- Table of Contents
Facts about E3 ubiquitin-protein ligase RNF138.
Two distinct, non-exclusive, mechanisms have been proposed. According to a report, regulates the option of double-strand fracture repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to eliminate the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055).
Human | |
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Gene Name: | RNF138 |
Uniprot: | Q8WVD3 |
Entrez: | 51444 |
Belongs to: |
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No superfamily |
E3 ubiquitin-protein ligase RNF138; EC 6.3.2.-; hNARF; HSD-4; MGC8758; NARF; Nemo-like kinase-associated RING finger protein; ring finger protein 138NLK-associated RING finger protein; STRIN
Mass (kDA):
28.193 kDA
Human | |
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Location: | 18q12.1 |
Sequence: | 18; NC_000018.10 (32091858..32131561) |
Chromosome. Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057).
PMID: 16714285 by Yamada M., et al. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).
PMID: 26502055 by Ismail I.H., et al. The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.