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- Table of Contents
Facts about Regulator of microtubule dynamics protein 3.
Overexpression induces apoptosis. .
Human | |
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Gene Name: | RMDN3 |
Uniprot: | Q96TC7 |
Entrez: | 55177 |
Belongs to: |
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RMDN family |
Cerebral protein 10; FAM82Cmicrotubule-associated protein; family with sequence similarity 82, member A2; FLJ10579; hRMD-3; Protein FAM82A2; Protein FAM82C; Protein tyrosine phosphatase-interacting protein 51; ptpip51; PTPIP51family with sequence similarity 82, member C; regulator of microtubule dynamics 3; regulator of microtubule dynamics protein 3; RMD3; RMD-3; TCPTP-interacting protein 51
Mass (kDA):
52.118 kDA
Human | |
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Location: | 15q15.1 |
Sequence: | 15; NC_000015.10 (40735884..40755336, complement) |
Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
PMID: 18070910 by Oishi K., et al. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans.
PMID: 15609043 by Stenzinger A., et al. The novel protein PTPIP51 exhibits tissue- and cell-specific expression.