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- Table of Contents
Facts about Rapamycin-insensitive companion of mTOR.
MTORC2 seems to work upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. MTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
Mouse | |
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Gene Name: | Rictor |
Uniprot: | Q6QI06 |
Entrez: | 78757 |
Belongs to: |
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RICTOR family |
AVO3 homolog; AVO3; hAVO3; KIAA1999DKFZp686B11164; mAVO3; MGC39830; PIA; Pianissimo; rapamycin-insensitive companion of mTOR; Rictor; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
Mass (kDA):
191.57 kDA
Mouse | |
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Location: | 15|15 A1 |
Sequence: | 15; |
PMID: 15467718 by Jacinto E., et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
PMID: 16962829 by Shiota C., et al. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.