Protein RIC-3 Antibodies

AND RIC3 ELISA kits, Protein RIC-3 Proteins

Many biological assays use antibodies to detect Protein RIC-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein RIC-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein RIC-3 antibodies...

We validate the specificity of these antibodies to Protein RIC-3 by testing them on tissues known to express RIC3 positively and negatively. Browse below to find the RIC3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RIC3 Infographic by Boster Bio

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RIC3 (NM_024557) Human Over-expression Lysate

Human

$628
Cat # LS079608
100 µg

RIC3 Overview

Facts about Protein RIC-3.

RIC3 3D structure. Source: alphafold

Protein RIC-3 (RIC3)

Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote practical expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.

Gene Information

Human
Gene Name:	RIC3
Uniprot:	Q7Z5B4
Entrez:	79608

Family

Belongs to:

ric-3 family

Alternative Names

AYST720; FLJ11608; PRO1385; protein RIC-3; resistance to inhibitors of cholinesterase 3 homolog (C. elegans)

Molecular Weight

Mass (kDA):
41.092 kDA

Genomic Context


Human

Location:	11p15.4
Sequence:	11; NC_000011.10 (8092965..8169040, complement)

Tissue Specificity

Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain.

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Diseases

Nervousness
Schizophrenia
Diabetes Mellitus
Infective Disorder
Myeloproliferative Syndrome, Transient
Neuroblastoma
Cross Infection
Obesity, Abdominal
Postmortem Changes
Psychotic Disorders
Epilepsy
Pneumonia

Diabetes Mellitus, Non-insulin-dependent
Hemorrhage
Obesity
Surgical Wound Infection
Inflammation
Nosocomial Infection
Alzheimer's Disease

Pathways

Transport
Localization
Synaptic Transmission
Pollen Tube Growth
Vesicle Targeting
Receptor Clustering
Regulation Of Signal Transduction
Proteolysis
M Phase
Anaphase
Nuclear Division

Dna Replication
Translation
Receptor Internalization
Cell Cycle
Exocytosis

PTMs

Acetylation

Isopeptide bond

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIC3

References

PMID: 12821669 by Halevi S., et al. Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression.

PMID: 18691158 by Seredenina T., et al. Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors.