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- Table of Contents
Facts about Rho-related GTP-binding protein RhoU.
Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Human | |
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Gene Name: | RHOU |
Uniprot: | Q7L0Q8 |
Entrez: | 58480 |
Belongs to: |
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small GTPase superfamily |
ARHU; CDC42L1GTP-binding protein-like 1; DJ646B12.2; fJ646B12.2; FLJ10616,2310026M05Rik; G28K; GTP-binding protein like 1; GTP-binding protein SB128; hG28K; ras homolog gene family, member U; ras-like gene family member U; Rho GTPase-like protein ARHU; rho-related GTP-binding protein RhoU; Ryu GTPase; Wnt-1 responsive Cdc42 homolog 1; WRCH-1; WRCH1CDC42-like GTPase 1
Mass (kDA):
28.218 kDA
Human | |
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Location: | 1q42.13 |
Sequence: | 1; NC_000001.11 (228644647..228746669) |
Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Localizes to podosomes in SRC-transformed cells.
PMID: 11459829 by Tao W., et al. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
PMID: 11894124 by Kirikoshi H., et al. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells.