RGS6 Antibodies

AND RGS6 ELISA kits, RGS6 Proteins

Many biological assays use antibodies to detect RGS6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RGS6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RGS6 antibodies...

We validate the specificity of these antibodies to RGS6 by testing them on tissues known to express RGS6 positively and negatively. Browse below to find the RGS6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RGS6 Infographic by Boster Bio

All RGS6 Products

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Product

Figures

Specificity

Applications

Price

Anti-RGS6 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A05753-1
100 μg/vial

Anti-RGS6 Rabbit Monoclonal Antibody

Human

$370
Cat # M05753
100 μl/vial

RGS6 (NM_004296) Human Over-expression Lysate

Human

$628
Cat # LS009628
100 µg

RGS6 Overview

Facts about Regulator of G-protein signaling 6.

RGS6 3D structure. Source: alphafold

Regulator of G-protein signaling 6 (RGS6)

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.

The RGS6/GNB5 dimer enriches GNAO1 GTPase activity (PubMed:10521509). .

Gene Information

Human
Gene Name:	RGS6
Uniprot:	P49758
Entrez:	9628

Family

Belongs to:

No superfamily

Alternative Names

DKFZp313G1241; FLJ43552; G protein signaling 6 regulator; GAP; GTPase activating protein; H_DJ0283M22.1; H_DJ1108A12.1; MGC142132; regulator of G protein signaling 6; regulator of G protein signalling 6; regulator of G-protein signaling 6; regulator of G-protein signalling 6; S914; WUGSC:H_DJ0283M22.1; WUGSC:H_DJ1108A12.1

Molecular Weight

Mass (kDA):
54.423 kDA

Genomic Context


Human

Location:	14q24.2
Sequence:	14; NC_000014.9 (71867397..72632478)

Subcellular Localizations

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cell membrane. Interaction with GNB5 mediates translocation to the nucleus.

Diseases

Malignant Neoplasms
Nervousness
Heart Failure
Bradycardia
Ataxia
Hypertrophy
Insulin Resistance
Neuroblastoma
Cell Transformation, Neoplastic
Atherosclerosis
Malignant Neoplasm Of Breast
Cardiac Hypertrophy
Malignant Neoplasm Of Urinary Bladder

Chronic Congestive Heart Failure
Brain Infarction
Neoplasms
Cytomegalovirus Infections
Mammary Neoplasms
Pheochromocytoma
Ovarian Neoplasm

Interacting Proteins

HSP90AB1

Pathways

Localization
Response To Stress
Membrane Hyperpolarization
Synaptic Transmission
Cell Death
Cell Cycle
Regulation Of Heart Rate
Cell Activation
Regulation Of Cell Activation
Mitochondrial Outer Membrane Permeabilization
Response To Heat
Cell Cycle Arrest
Negative Regulation Of Cell Activation

Translation
Nuclear Migration
Cell Differentiation
Cell Growth
Phototransduction
Mating
Regulation Of Synaptic Transmission

PTMs

Phosphorylation

Cleavage

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RGS6

References

PMID: 12761221 by Chatterjee T.K., et al. Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants.

PMID: 10339615 by Snow B.E., et al. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.