RGS2 Antibodies

AND RGS2 ELISA kits, RGS2 Proteins

Many biological assays use antibodies to detect RGS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RGS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RGS2 antibodies...

We validate the specificity of these antibodies to RGS2 by testing them on tissues known to express RGS2 positively and negatively. Browse below to find the RGS2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RGS2 Infographic by Boster Bio

All RGS2 Products

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Product

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Specificity

Applications

Price

Human RGS2 Recombinant Protein

SDS-PAGE

$287
Cat # PROTP41220
Starting from 10ug

RGS2 (NM_002923) Human Over-expression Lysate

Human

$628
Cat # LS005997
100 µg

RGS2 Overview

Facts about Regulator of G-protein signaling 2.

RGS2 3D structure. Source: alphafold

Regulator of G-protein signaling 2 (RGS2)

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087).

It is involved in the negative regulation of this angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ.

Gene Information

Human
Gene Name:	RGS2
Uniprot:	P41220
Entrez:	5997

Family

Belongs to:

No superfamily

Alternative Names

Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8, 24kD; G0/G1 switch regulatory protein 8; G0S8cell growth-inhibiting protein 31; regulator of G-protein signaling 2; regulator of G-protein signaling 2, 24kDa; regulator of G-protein signalling 2, 24kD; regulator of G-protein signalling 2, 24kDa

Molecular Weight

Mass (kDA):
24.382 kDA

Genomic Context


Human

Location:	1q31.2
Sequence:	1; NC_000001.11 (192809039..192812275)

Tissue Specificity

Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).

Subcellular Localizations

[Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 3]: Cell membrane. Cytoplasm. Nucleus, nucleolus.; [Isoform 4]: Cell membrane. Mitochondrion.

Diseases

Hypertensive Disease
Pertussis
Hypertrophy
Malignant Neoplasms
Anxiety Disorders
Heart Failure
Neoplasms
Nervousness
Cardiovascular Diseases
Pathologic Vasoconstriction
Schizophrenia
Cardiac Hypertrophy
Panic Disorder

Mental Disorders
Neoplasm Metastasis
Essential Hypertension
Neuroblastoma
Secondary Parkinson Disease
Obesity
Carcinoma

Interacting Proteins

Gnaq
LRRK2
MTUS2
PPP1R9A

Pathways

Localization
Secretion
Pathogenesis
Transport
Cell Growth
Cell Migration
Cell Proliferation
Translation
Cell Cycle
Cell Differentiation
Rna Interference
Excretion
Chemotaxis

Sensitization
Cell Activation
Response To Stress
Immune Response
Chondrocyte Differentiation
Cell Division
Fibroblast Activation

PTMs

Phosphorylation
Dephosphorylation
Cleavage
Sumoylation
Nitrosylation
Prenylation

Ribosylation
Biotinylation
Glycosylation
Acetylation
Methylation
Oxidation

Palmitoylation

Research Areas

Cell Cycle and Replication
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RGS2

References

PMID: 8179820 by Siderovski D.P., et al. A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.

PMID: 11278586 by Heximer S.P., et al. Mechanisms governing subcellular localization and function of human RGS2.