Raftlin Antibodies

AND RFTN1 ELISA kits, Raftlin Proteins

Many biological assays use antibodies to detect Raftlin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Raftlin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Raftlin antibodies...

We validate the specificity of these antibodies to Raftlin by testing them on tissues known to express RFTN1 positively and negatively. Browse below to find the RFTN1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RFTN1 Infographic by Boster Bio

All RFTN1 Products

Product

Figures

Specificity

Applications

Price

Anti-Raftlin RFTN1 Antibody

5 Q&As

Human

$399
Cat # A11324
100μl

Anti-Raftlin RFTN1 Antibody

Human, Mouse, Rat

$405
Cat # A11324-1
100ul

RFTN1 (NM_015150) Human Over-expression Lysate

Human

$960
Cat # LS023180
100 µg

Anti-RFTN1 Antibody Picoband™

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A11324-2
100 µg/vial

RFTN1 Overview

Facts about Raftlin.

RFTN1 3D structure. Source: alphafold

Raftlin (RFTN1)

Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 into endosomes in dendritic cells and macrophages; and internalization of poly(I:C) into TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; leading to activation of TICAM1-mediated signaling and following IFNB1 production (PubMed:27022195, PubMed:21266579).

Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor- mediated signaling (PubMed:12805216).

Gene Information

Human
Gene Name:	RFTN1
Uniprot:	Q14699
Entrez:	23180

Family

Belongs to:

raftlin family

Alternative Names

MIG2; PIB10; PIG9; RAFTLIN; RFTN1 raftlin, lipid raft linker 1

Molecular Weight

Mass (kDA):
63.146 kDA

Genomic Context


Human

Location:	3p24.3
Sequence:	3; NC_000003.12 (16315845..16513699, complement)

Tissue Specificity

Expressed in B-cells (at protein level) (PubMed:12805216). Expressed in dendritic cells and macrophages (PubMed:27022195, PubMed:21266579).

Subcellular Localizations

Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft. Endosome. Early endosome. Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195).

Diseases

Glaucoma
Optic Nerve Hypoplasia
Hypoplasia
Intraocular Pressure Disorder
Glaucoma, Open-angle
Blind Vision

Primary Open Angle Glaucoma

PTMs

Lipoprotein
Myristate

Palmitate
Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RFTN1

References

PMID: 12805216 by Saeki K., et al. The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.

PMID: 20213681 by Suzuki T., et al. Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.