REST Antibodies

AND REST ELISA kits, REST Proteins

Many biological assays use antibodies to detect REST, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with REST in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop REST antibodies...

We validate the specificity of these antibodies to REST by testing them on tissues known to express REST positively and negatively. Browse below to find the REST antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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REST Infographic by Boster Bio

All REST Products

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Anti-REST Antibody

5 Q&As

Human

$360
Cat # A03852
100 µl

Anti-REST / NRSF Rabbit Monoclonal Antibody

Human

$370
Cat # M03852
100 μl/vial

REST Overview

Facts about RE1-silencing transcription factor.

REST 3D structure. Source: alphafold

RE1-silencing transcription factor (REST)

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two different corepressors, mSin3 and CoREST, which then recruit histone deacetylase to the promoters of REST-regulated genes.

Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL through the recruitment of histone methyltransferase EHMT2 might be significant in transformation suppression.

Gene Information

Human
Gene Name:	REST
Uniprot:	Q13127
Entrez:	5978

Family

Belongs to:

No superfamily

Alternative Names

Neural-restrictive silencer factor; NRSFneuron restrictive silencer factor; RE1-silencing transcription factor; X2 box repressor; XBRrepressor binding to the X2 box

Molecular Weight

Mass (kDA):
121.872 kDA

Genomic Context


Human

Location:	4q12
Sequence:	4; NC_000004.12 (56907900..56935847)

Tissue Specificity

Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary.

Subcellular Localizations

Nucleus. Cytoplasm. Colocalizes with ZFP90 in the nucleus (By similarity). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (PubMed:27531581). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (PubMed:24670762, PubMed:30684677).; [Isoform 2]: Cytoplasm.; [Isoform 3]: Nucleus.; [Isoform 4]: Cytoplasm.