Recombining binding protein suppressor of hairless (RBPJ)

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins.

When associated with some NICD product of Notch proteins (Notch intracellular domain), it functions as a transcriptional activator that activates transcription of Notch target genes. Likely represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively.