Retinol-binding protein 2 Antibodies

Retinol-binding protein 2 (RBP2)

Intracellular transport of retinol. .

Gene Information

Human
Gene Name:	RBP2
Uniprot:	P50120
Entrez:	5948

Family

Belongs to:
calycin superfamily

Alternative Names

Cellular retinol-binding protein II; cellular; CRABP-II; CRBP2CRBP-II; retinol binding protein 2, cellular

Molecular Weight

Mass (kDA):
15.707 kDA

Genomic Context

Human
Location:	3q23
Sequence:	3; NC_000003.12 (139452884..139476516, complement)

Tissue Specificity

Higher expression in adult small intestine and to a much lesser extent in fetal kidney.

Subcellular Localizations

Cytoplasm.

Diseases

• Retinoblastoma
• Neoplasms
• Malignant Neoplasms
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Breast
• Carcinoma
• Mammary Neoplasms
• Cell Transformation, Neoplastic
• Kidney Failure, Chronic
• Kidney Failure
• Melanoma
• Refractory Anemia With Ringed Sideroblasts
• Adenocarcinoma

• Tissue Adhesions
• Malignant Neoplasm Of Stomach
• Hyperplasia
• Stomach Neoplasms
• Malignant Tumor Of Cervix
• Hereditary Diseases
• Inflammation

Pathways

• Methylation
• Histone Methylation
• Demethylation
• Transport
• Cell Proliferation
• Localization
• Cell Differentiation
• Histone Modification
• Retinol Transport
• Intestinal Absorption
• Reverse Transcription
• Cell Cycle
• Histone Acetylation

• Chromatin Remodeling
• Dna Repair
• Blood Circulation
• Secretion
• Neural Tube Closure
• Gene Silencing
• Cellular Senescence

PTMs

• Methylation
• Demethylation
• Phosphorylation
• Acetylation
• Carboxylation

• Reduction
• Hydroxylation
• Deacetylation
• Cleavage
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBP2

Boster Bio - Best Uses Of The RBP2 Marker

If you have never heard of the Anti-Retinol-Binding Protein 2 (RBP2) Marker, this article is for you. Learn more about this marker and how it can optimize your experiments. The RBP2 marker plays an important role in skin health. A high-quality product will deliver the results you desire. These are the most important Boster Bio tip and trick suggestions.

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Anti-Retinol-Binding Protein 2 RBP2 Marker

Retinol is bound by a protein called RBP2. This protein is a lipid-carrier and it channels retinol along with other lipids to LRAT. Retinol is present in the retina, and RBP2 binds to it in a tight, noncovalent manner.

RBP2 expression is closely related to the differentiation of Caco-2 cell lines and their confluence. Treatment with retinoic is increases RBP2 and retinol intake. However, this effect only occurs in post-confluent differentiated Caco-2 cells and not in proliferating undifferentiated cells. The proximal 2.8kb region of RBP2 gene appears to be the key to its effect on expression.

RBP2 is yet to be identified but it is known that it is a retinoidbinding protein that is involved in regulating CDH, BPES. This is why this protein is highly expressed in the intestine. It is found in almost all tissues of our bodies, including the skin, blood, gastrointestinal tract, and hair.

The modulation of the CRBPs of keratinocytes controls the skin's effect of retinolbinding protein-2. CRBPs regulate the activities and metabolism of retinol within the skin. It also regulates HAS3 gene regulation, which helps adjust dosages for patients who are on base C.

Computer-based prediction identified 21 H-2Kb/Db-binding retinal protein and soluble retinal antibody. RXRa, PPARa, and ETYA all bound to response elements in vitro. 9-cis retinoic acids and arachidonic acid also enhanced their binding activities. This suggests that dietary fat acids regulate RBP2 expression through RXR and PPAR heterodimers that are bound to response elements within retinal cells.

RBP2 is an essential component of gut retinol metabolism. It also contributes to intestinal nutrient sensing and neutral lipid metabolism. Its actions in the gut are not fully understood. The anti-retinol-binding proteins 2 RBP2 marker is useful in diagnosing and treating skin diseases.