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RBBP4 Antibodies
AND RBBP4 ELISA kits, RBBP4 Proteins
Many biological assays use antibodies to detect RBBP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RBBP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RBBP4 antibodies...
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RBBP4 Infographic by Boster Bio
All RBBP4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC-F, ICC, WB
$370
Cat # PB9797
100 μg/vial
Cat # PB9797
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02702
100 μl
Cat # M02702
100 μl
Human, Mouse, Rat
IHC, WB
$370
Cat # M02702-1
100 μg/vial
Cat # M02702-1
100 μg/vial
RBBP4 Overview
Facts about Histone-binding protein RBBP4.
Histone-binding protein RBBP4 (RBBP4)
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.
These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during evolution; and the NURF (nucleosome remodeling factor) complex. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RBBP4 |
| Uniprot: | Q09028 |
| Entrez: | 5928 |
Family
| Belongs to: |
|---|
| WD repeat RBAP46/RBAP48/MSI1 family |
Alternative Names
CAF-1 p48; CAF-1 subunit C; CAF-1C; CAF-I p48; Chromatin assembly factor 1 subunit C; Chromatin assembly factor I p48 subunit; chromatin assembly factor/CAF-1 p48 subunit; histone-binding protein RBBP4; MSI1 protein homolog; Nucleosome-remodeling factor subunit RBAP48; NURF55; RBAP48; RBBP4; RBBP-4; retinoblastoma binding protein 4; Retinoblastoma-binding protein 4CAF-I 48 kDa subunit; Retinoblastoma-binding protein p48
Molecular Weight
Mass (kDA):
47.656 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.1 |
| Sequence: | 1; NC_000001.11 (32651208..32686211) |
Subcellular Localizations
Nucleus.
Diseases
- Retinoblastoma
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Myeloid Leukemia
- Leukemia
- Mammary Neoplasms
- Liver Carcinoma
- Liver Neoplasms
- Leukemia, Myelocytic, Acute
- Oestrogen Deficiency
- Autoimmune Reaction
Interacting Proteins
- HAT1
- HDAC1
- MECOM
- MTA1
- PRDM16
- ZFPM1
Pathways
- Cell Cycle
- Cell Proliferation
- Methylation
- Histone Acetylation
- Histone Deacetylation
- Localization
- Dna Replication
- S Phase
- Cell Growth
- Gene Silencing
- Histone Methylation
- Chromatin Remodeling
- Dna Repair
PTMs
- Deacetylation
- Phosphorylation
- Methylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- Growth and Development
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBBP4
bosterbio.com/bosterbio-gene-info-cards/RBBP4
References
PMID: 8350924 by Qian Y.-W., et al. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast.
PMID: 1699755 by Bauw G., et al. Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.