Ras association domain-containing protein 5 (Rassf5)

Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation.

Isoform 2 stimulates lymphocyte polarization and the patch-like supply of ITGAL/LFA-1, leading to an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth.