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- Table of Contents
Facts about Plakophilin-3.
Human | |
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Gene Name: | PKP3 |
Uniprot: | Q9Y446 |
Entrez: | 11187 |
Belongs to: |
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beta-catenin family |
plakophilin 3; plakophilin-3
Mass (kDA):
87.082 kDA
Human | |
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Location: | 11p15.5 |
Sequence: | 11; NC_000011.10 (392596..404908) |
Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.
Nucleus. Cell junction, desmosome. Nuclear and associated with desmosomes.
PMID: 10374265 by Schmidt A., et al. Plakophilin 3 -- a novel cell-type-specific desmosomal plaque protein.
PMID: 10381383 by Bonne S., et al. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells.