RASGRP1 Antibodies

AND RASGRP1 ELISA kits, RASGRP1 Proteins

Many biological assays use antibodies to detect RASGRP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RASGRP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RASGRP1 antibodies...

We validate the specificity of these antibodies to RASGRP1 by testing them on tissues known to express RASGRP1 positively and negatively. Browse below to find the RASGRP1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RASGRP1 Infographic by Boster Bio

All RASGRP1 Products

Product

Figures

Specificity

Applications

Price

Anti-RAS guanyl-releasing protein 1 RASGRP1 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A03004
100ul

RASGRP1 (NM_005739) Human Over-expression Lysate

Human

$960
Cat # LS010125
100 µg

Anti-RASGRP1 Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A03004-1
100 µg/vial

RASGRP1 Overview

Facts about RAS guanyl-releasing protein 1.

RASGRP1 3D structure. Source: alphafold

RAS guanyl-releasing protein 1 (RASGRP1)

Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849).

Regulates T-cell/B-cell growth, homeostasis and differentiation by coupling T-lymphocyte/B- lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM- dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860).

Gene Information

Human
Gene Name:	RASGRP1
Uniprot:	O95267
Entrez:	10125

Family

Belongs to:

RASGRP family

Alternative Names

RAS guanyl-releasing protein 1; CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RASGRP

Molecular Weight

Mass (kDA):
90.402 kDA

Genomic Context


Human

Location:	15q14
Sequence:	15; NC_000015.10 (38488097..38564814, complement)

Tissue Specificity

Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).

Subcellular Localizations

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity).