This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Ras GTPase-activating protein 1.
Inhibitory regulator of This Ras-cyclic AMP pathway.
Stimulates the GTPase of ordinary but not oncogenic Ras p21; this stimulation might be further increased in the presence of NCK1..
Human | |
---|---|
Gene Name: | RASA1 |
Uniprot: | P20936 |
Entrez: | 5921 |
Belongs to: |
---|
No superfamily |
CM-AVM; PKWS; RASA1; RasGAP; Ras-GAP
Mass (kDA):
116.403 kDA
Human | |
---|---|
Location: | 5q14.3 |
Sequence: | 5; NC_000005.10 (87267845..87391926) |
In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
Cytoplasm.
PMID: 3201259 by Trahey M., et al. Molecular cloning of two types of GAP complementary DNA from human placenta.
PMID: 8360177 by Zhang Y., et al. Purification, characterization, and cellular localization of the 100- kDa human placental GTPase-activating protein.