RAPGEF4 Antibodies

AND RAPGEF4 ELISA kits, RAPGEF4 Proteins

Many biological assays use antibodies to detect RAPGEF4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAPGEF4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAPGEF4 antibodies...

We validate the specificity of these antibodies to RAPGEF4 by testing them on tissues known to express RAPGEF4 positively and negatively. Browse below to find the RAPGEF4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RAPGEF4 Infographic by Boster Bio

All RAPGEF4 Products

Product

Figures

Specificity

Applications

Price

Anti-EPAC2 RAPGEF4 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A04794
0.1 mg

Epac2 (RAPGEF4) (NM_007023) Human Recombinant Protein

$1249
Cat # PROTQ8WZA2
20 µg

Anti-Epac2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M04794
100 μl/vial

Epac2 (RAPGEF4) (NM_007023) Human Over-expression Lysate

Human

$628
Cat # LS011069
100 µg

RAPGEF4 Overview

Facts about Rap guanine nucleotide exchange factor 4.

RAPGEF4 3D structure. Source: alphafold

Rap guanine nucleotide exchange factor 4 (RAPGEF4)

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases which is triggered by binding cAMP. Seems not to trigger RAB3A.

Involved in cAMP-dependent, PKA- independent exocytosis through discussion with RIMS2 (By similarity). .

Gene Information

Human
Gene Name:	RAPGEF4
Uniprot:	Q8WZA2
Entrez:	11069

Family

Belongs to:

No superfamily

Alternative Names

CAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CGEF2EPAC 2; EPAC2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; Nbla00496; putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; rap guanine nucleotide exchange factor 4; RAP guanine-nucleotide-exchange factor (GEF) 4

Molecular Weight

Mass (kDA):
115.522 kDA

Genomic Context


Human

Location:	2q31.1
Sequence:	2; NC_000002.12 (172735282..173052893)

Tissue Specificity

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein.

Diseases

Tissue Adhesions
Diabetes Mellitus
Autistic Disorder
Pituitary Diseases
Diabetes Mellitus, Non-insulin-dependent
Hypertrophy
Melanoma
Malignant Neoplasms
Neoplasm Metastasis
Cardiac Hypertrophy
Neoplasms
Metastatic Melanoma
Depressive Disorder

Inflammation
Learning Disorders
Malnutrition
Lung Diseases
Infertility
Carcinoma
Lung Diseases, Obstructive

Interacting Proteins

C16orf45

Pathways

Secretion
Insulin Secretion
Exocytosis
Cell Adhesion
Cell Migration
Localization
Transport
Translation
Cognition
Hormone Secretion
Cell Proliferation
Ion Transport
Response To Camp

Fertilization
Spermatogenesis
Membrane Depolarization
Chemotaxis
Cell Differentiation
Cell Chemotaxis
Glucagon Secretion

PTMs

Phosphorylation

Cleavage

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAPGEF4

References

PMID: 9856955 by Kawasaki H., et al. A family of cAMP-binding proteins that directly activate rap1.

PMID: 11707077 by Ueno H., et al. Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver- specific isoform.