RAP1A Antibodies

AND RAP1A ELISA kits, RAP1A Proteins

Many biological assays use antibodies to detect RAP1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAP1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAP1A antibodies...

We validate the specificity of these antibodies to RAP1A by testing them on tissues known to express RAP1A positively and negatively. Browse below to find the RAP1A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RAP1A Infographic by Boster Bio

All RAP1A Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-RAP1A Antibody Picoband®

2 Q&As

Human, Mouse, Rat

$370
Cat # PB9816
100 μg/vial

Human Rap1A Recombinant Protein

SDS-PAGE

$265
Cat # PROTP62834
Starting from 10ug

RAP1A (NM_002884) Human Over-expression Lysate

Human

$628
Cat # LS005906
100 µg

RAP1A Overview

Facts about Ras-related protein Rap-1A.

RAP1A 3D structure. Source: alphafold

Ras-related protein Rap-1A (RAP1A)

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner.

Together with ITGB1BP1, modulates KRIT1 localization into microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.

Gene Information

Human
Gene Name:	RAP1A
Uniprot:	P62834
Entrez:	5906

Family

Belongs to:

small GTPase superfamily

Alternative Names

C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1Ras-related protein Krev-1; RAP1; Rap1A; RAP1A, member of RAS oncogene family; RAS-related protein RAP1A; ras-related protein Rap-1A; SMGP21

Molecular Weight

Mass (kDA):
20.987 kDA

Genomic Context


Human

Location:	1p13.2
Sequence:	1; NC_000001.11 (111542009..111716695)

Subcellular Localizations

Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.

Diseases

Malignant Neoplasms
Tissue Adhesions
Neoplasms
Leukemia
Neoplasm Metastasis
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Mammary Neoplasms
Carcinoma
Cavernous Hemangioma Of Brain
Tumor Angiogenesis

Malignant Paraganglionic Neoplasm
Osteoporosis
Metaplastic Cell Transformation
Inflammation
Multiple Myeloma
Lung Neoplasms

Interacting Proteins

RAF1
Rassf5

Pathways

Prenylation
Localization
Cell Adhesion
Cell Proliferation
Integrin Activation
Cell Cycle
Protein Prenylation
Pathogenesis
Cell Growth
Bone Resorption
Cell Migration
Angiogenesis
Cell Death

Secretion
Cell Activation
Phagocytosis
Protein Geranylgeranylation
Chemotaxis
Respiratory Burst
Cell-cell Adhesion

PTMs

Prenylation
Phosphorylation
Farnesylation
Geranylgeranylation
Formylation

Cleavage
Acetylation
Dephosphorylation
Ribosylation
Palmitoylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAP1A

References

PMID: 3045729 by Pizon V., et al. Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

PMID: 2507536 by Nagata K., et al. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein.