RAP1B Antibodies

AND RAP1B ELISA kits, RAP1B Proteins

Many biological assays use antibodies to detect RAP1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAP1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAP1B antibodies...

We validate the specificity of these antibodies to RAP1B by testing them on tissues known to express RAP1B positively and negatively. Browse below to find the RAP1B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RAP1B Infographic by Boster Bio

All RAP1B Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human, Mouse

IF, ICC, WB

$405
Cat # A02596
100ul

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02596-1
100ul

RAP1B (NM_001010942) Human Recombinant Protein

$813
Cat # PROTP61224
20 µg

RAP1B (NM_015646) Human Over-expression Lysate

Human

$628
Cat # LS005908
100 µg

RAP1B Overview

Facts about Ras-related protein Rap-1b.

RAP1B 3D structure. Source: alphafold

Ras-related protein Rap-1b (RAP1B)

GTP-binding protein which possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.

Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 into the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Gene Information

Human
Gene Name:	RAP1B
Uniprot:	P61224
Entrez:	5908

Family

Belongs to:

small GTPase superfamily

Alternative Names

DKFZp586H0723; GTP-binding protein smg p21B; KREV; K-REV; RAL1B; Rap1B; RAP1B, member of RAS oncogene family; Ras family small GTP binding protein RAP1B; RAS-related protein RAP1B; ras-related protein Rap-1b; small GTP binding protein

Molecular Weight

Mass (kDA):
20.825 kDA

Genomic Context


Human

Location:	12q15
Sequence:	12; NC_000012.12 (68610899..68671901)

Subcellular Localizations

Cell membrane. Cytoplasm, cytosol. Cell junction. May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.

Diseases

Tissue Adhesions
Neoplasms
Malignant Neoplasms
Carcinoma
Thrombus
Thrombosis
Cell Transformation, Neoplastic
Diabetic Nephropathy
Hemorrhage
Kidney Diseases
Tumor Angiogenesis
Malignant Paraganglionic Neoplasm
Glioma

Carcinogenesis
Arterial Thrombosis
Adenoma
Diabetes Mellitus
Cerebrovascular Accident
Hyperglycemia
Dysmyelopoietic Syndromes

Interacting Proteins

RALGDS
RAP1GAP
RASSF5

Pathways

Platelet Aggregation
Platelet Activation
Localization
Cell Proliferation
Cell Adhesion
Secretion
Integrin Activation
Chemotaxis
Cell Activation
Cell Cycle
Cell Growth
Angiogenesis
Cell Migration

Translation
S Phase
Pathogenesis
Transport
Reverse Transcription
Phagocytosis
Wound Healing

PTMs

Phosphorylation
Farnesylation
Prenylation
Cleavage
Geranylgeranylation

Ubiquitination
Glycosylation
Methylation
Dephosphorylation
Ribosylation

Palmitoylation

Research Areas

Endosome Markers
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAP1B

References

PMID: 3137530 by Pizon V., et al. Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).

PMID: 3141412 by Bokoch G.M., et al. Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.