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- Table of Contents
Facts about Ran GTPase-activating protein 1.
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860).
Converts cytoplasmic GTP-bound RAN into GDP-bound RAN, which is vital for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050).Mediates dissociation of cargo from nuclear export complexes comprising XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). .
Human | |
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Gene Name: | RANGAP1 |
Uniprot: | P46060 |
Entrez: | 5905 |
Belongs to: |
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RNA1 family |
Fug1; KIAA1835Fug1; MGC20266; Ran GTPase activating protein 1; ran GTPase-activating protein 1; RanGAP1; SD; segregation distorter homolog (Drosophila); segregation distorter homolog; segregation distortion
Mass (kDA):
63.542 kDA
Human | |
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Location: | 22q13.2 |
Sequence: | 22; NC_000022.11 (41244779..41302369, complement) |
Highly expressed in brain, thymus and testis.
Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requ
PMID: 7878053 by Bischoff F.R., et al. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.
PMID: 8146159 by Bischoff F.R., et al. RanGAP1 induces GTPase activity of nuclear Ras-related Ran.