RANBP2 Antibodies

AND RANBP2 ELISA kits, RANBP2 Proteins

Many biological assays use antibodies to detect RANBP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RANBP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RANBP2 antibodies...

We validate the specificity of these antibodies to RANBP2 by testing them on tissues known to express RANBP2 positively and negatively. Browse below to find the RANBP2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RANBP2 Infographic by Boster Bio

All RANBP2 Products

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Anti-RanBP2 Antibody Picoband®

5 Q&As

Human, Mouse, Rat

$370
Cat # A00981
100 μg/vial

Anti-RANBP2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00981-1
100 µg/vial

RANBP2 Overview

Facts about E3 SUMO-protein ligase RanBP2.

E3 SUMO-protein ligase RanBP2 (RANBP2)

E3 SUMO-protein ligase which Eases SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224).
Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import through the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481).

May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529).

Gene Information

Human
Gene Name:	RANBP2
Uniprot:	P49792
Entrez:	5903

Family

Belongs to:

RanBP2 E3 ligase family

Alternative Names

ANE1; E3 SUMO-protein ligase RanBP2; EC 5.2.1.8; Nuclear pore complex protein Nup358; nucleoporin 358; Nucleoporin Nup358; NUP358TRP2; p270; RAN binding protein 2; Ran-binding protein 2; RanBP2; transformation-related protein 2,358 kDa nucleoporin; TRP1

Molecular Weight

Mass (kDA):
358.199 kDA

Genomic Context


Human

Location:	2q13
Sequence:	2; NC_000002.12 (108719446..108785809)

Subcellular Localizations

Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Nucleus envelope. Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481).

Diseases

Virus Diseases
Encephalopathies
Malignant Neoplasms
Leukoencephalitis, Acute Hemorrhagic
Neoplasms
Infective Disorder
Hiv Infections
Immunologic Deficiency Syndromes
Comatose
Adenocarcinoma
Influenza
Haploinsufficiency

Cell Transformation, Neoplastic
Parkinson Disease
Secondary Parkinson Disease
Aneuploidy
Neurodegenerative Disorders
Nervous System Disorder

Interacting Proteins

BICD2
ERBB2
PDLIM3
PRKN
RAN

UBE2I

Pathways

Transport
Localization
Nuclear Import
Nucleocytoplasmic Transport
Nuclear Export
Conjugation
Protein Import
Mitosis
Nuclear Transport
Cell Cycle
Interphase
Anaphase
Spindle Assembly

Pathogenesis
Rna Interference
Cell Death
Cell Adhesion
Spermatogenesis
Cell Division
Energy Homeostasis

PTMs

Sumoylation
Phosphorylation
Cleavage

Ubiquitination
Acetylation
Deacetylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RANBP2

References

PMID: 7775481 by Wu J., et al. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region.

PMID: 7603572 by Yokoyama N., et al. A giant nucleopore protein that binds Ran/TC4.