RAN Antibodies

AND RAN ELISA kits, RAN Proteins

Many biological assays use antibodies to detect RAN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAN antibodies...

We validate the specificity of these antibodies to RAN by testing them on tissues known to express RAN positively and negatively. Browse below to find the RAN antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RAN Infographic by Boster Bio

All RAN Products

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Product

Figures

Specificity

Applications

Price

Anti-Ran Antibody Picoband®

17 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # A00204-1
100 μg/vial

Anti-Ran Monoclonal Antibody

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, ICC, WB

$370
Cat # M00204
100 μl

Anti-Ran Antibody Picoband® (monoclonal, 5D5)

6 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M00204-1
100 μg/vial

Anti-RAN (E202) Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A00204
100ul

Human RAN Recombinant Protein

SDS-PAGE

$265
Cat # PROTP62826
Starting from 10ug

RAN (NM_006325) Human Over-expression Lysate

Human

$628
Cat # LS005901
100 µg

RAN Overview

Facts about GTP-binding nuclear protein Ran.

RAN 3D structure. Source: alphafold

GTP-binding nuclear protein Ran (RAN)

GTPase involved in nucleocytoplasmic transport, Engaging both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610).
Switches between a cytoplasmic GDP- and a nuclear GTP-bound country by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610).

Nuclear import receptors like importin beta bind their substrates only in the lack of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while nitric oxide behave in the opposite manner. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644).

Gene Information

Human
Gene Name:	RAN
Uniprot:	P62826
Entrez:	5901

Family

Belongs to:

small GTPase superfamily

Alternative Names

Androgen receptor-associated protein 24; ARA24Gsp1; GTPase Ran; GTP-binding nuclear protein Ran; guanosine triphosphatase Ran; member RAS oncogene family; OK/SW-cl.81; RAN, member RAS oncogene family; RanGTPase; Ras-like protein TC4; Ras-related nuclear protein; TC4

Molecular Weight

Mass (kDA):
24.423 kDA

Genomic Context


Human

Location:	12q24.33
Sequence:	12; NC_000012.12 (130871879..130877678)

Tissue Specificity

Expressed in a variety of tissues.

Subcellular Localizations

Nucleus. Nucleus envelope. Cytoplasm, cytosol. Cytoplasm. Melanosome. Predominantly nuclear during interphase (PubMed:8421051, PubMed:12194828, PubMed:10679025). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:8421051, PubMed:12194828). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).