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- Table of Contents
16 Q&As
Facts about DNA repair protein RAD51 homolog 1.
Catalyzes the recognition of homology and strand exchange between homologous DNA spouses to form a joint molecule between a processed DNA break and the fix template. Binds to single-stranded DNA within an ATP-dependent manner to form nucleoprotein filaments that are essential for the homology search and strand exchange (PubMed:26681308).
Human | |
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Gene Name: | RAD51 |
Uniprot: | Q06609 |
Entrez: | 5888 |
Belongs to: |
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RecA family |
BRCC5; HRAD51; HsRad51; HsT16930; RAD51 (S. cerevisiae) homolog (E coli RecA homolog); RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog A; Rad51; RAD51ABRCA1/BRCA2-containing complex, subunit 5; RAD51L3; RecA, E. coli, homolog of; RECADNA repair protein RAD51 homolog 1; RecA-like protein; recombination protein A
Mass (kDA):
36.966 kDA
Human | |
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Location: | 15q15.1 |
Sequence: | 15; NC_000015.10 (40694774..40732340) |
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA da
PMID: 8358431 by Shinohara A., et al. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.
PMID: 8479919 by Yoshimura Y., et al. Cloning and sequence of the human RecA-like gene cDNA.