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- Table of Contents
, No Gclids
RAC1 Antibodies
AND RAC1 ELISA kits, RAC1 Proteins
Many biological assays use antibodies to detect RAC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAC1 antibodies...
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RAC1 Infographic by Boster Bio
All RAC1 Products
Product
Figures
Specificity
Applications
Price
Anti-Rac1 Antibody Picoband®
2 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9431
100 μg/vial
Cat # PB9431
100 μg/vial
Anti-Rac1/CDC42 Antibody
16 Q&As
Human, Mouse, Rat
ELISA, IHC-P, WB, IF (paraffin)
$335
Cat # A03252
100ul
Cat # A03252
100ul
RAC1 Overview
Facts about Ras-related C3 botulinum toxin substrate 1.
Ras-related C3 botulinum toxin substrate 1 (RAC1)
Plasma membrane-associated small GTPase which cycles between busy GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles.
Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAC1 |
| Uniprot: | P63000 |
| Entrez: | 5879 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
Cell migration-inducing gene 5 protein; MGC111543; p21-Rac1; p21-Rac1migration-inducing gene 5; Rac1; Ras-like protein TC25; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP bindingprotein Rac1); ras-related C3 botulinum toxin substrate 1; rho family, small GTP binding protein Rac1; TC25; TC-25
Molecular Weight
Mass (kDA):
21.45 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.1 |
| Sequence: | 7; NC_000007.14 (6374527..6403967) |
Tissue Specificity
Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasm. Cell projection, lamellipodium. Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). In macrophages, cytoplasmic location increases upon CSF1 stimulation (By simil
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Carcinoma
- Cell Transformation, Neoplastic
- Inflammation
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Nervousness
- Malignant Neoplasm Of Breast
Interacting Proteins
- ARFIP2
- ARHGAP45
- ARHGDIA
- ARHGEF7
- BAIAP2
- BIRC2
- CAV1
- CDC23
- CHN2
- DOCK1
Pathways
- Cell Migration
- Localization
- Cell Motility
- Cell Adhesion
- Cell Proliferation
- Secretion
- Cell Cycle
- Angiogenesis
- Phagocytosis
- Cell Death
- Cell Growth
- Pathogenesis
- Chemotaxis
PTMs
- Phosphorylation
- Ribosylation
- Prenylation
- Cleavage
- Dephosphorylation
- Geranylgeranylation
- Ubiquitination
- Methylation
- Acetylation
- Amidation
Research Areas
- Breast Cancer
- Cancer
- mTOR Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAC1
bosterbio.com/bosterbio-gene-info-cards/RAC1
References
PMID: 2674130 by Didsbury J., et al. Rac, a novel ras-related family of proteins that are botulinum toxin substrates.
PMID: 2108320 by Drivas G.T., et al. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
2 Publications of Boster RAC1 Antibodies & ELISA Kits
- PubMed ID: 28934273, Han F1, Zhuang TT1, Chen JJ1, Zhu XL1,2, Cai YF1, Lu YP1. PLoS One. 2017 Sep 21;...
- PubMed ID: 25037060, Shen L, Yang A, Yao P, Sun X, Chen C, Mo C, Shi L, Chen Y, Liu Q. Biometals. 201...
*More publications can be found for each product on its corresponding product page