Ras-related protein Rab-35 (RAB35)

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their combination with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that's able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.

That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the rapid recycling pathway back to the plasma membrane. During cytokinesis, required for its postfurrowing terminal steps, namely for intercellular bridge equilibrium and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization in the intercellular bridge.