TDRKH Antibodies

AND TDRKH ELISA kits, TDRKH Proteins

Many biological assays use antibodies to detect TDRKH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TDRKH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TDRKH antibodies...

We validate the specificity of these antibodies to TDRKH by testing them on tissues known to express TDRKH positively and negatively. Browse below to find the TDRKH antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TDRKH Infographic by Boster Bio

All TDRKH Products

Product

Figures

Specificity

Applications

Price

Anti-TDRKH Antibody

Human, Mouse, Rat

$405
Cat # A10373
100ul

TDRKH (NM_006862) Human Over-expression Lysate

Human

$960
Cat # LS011022
100 µg

TDRKH Overview

Facts about Tudor and KH domain-containing protein.

TDRKH 3D structure. Source: alphafold

Tudor and KH domain-containing protein (TDRKH)

Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and stop their mobilization, which is vital for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and regulate the methylation and subsequent repression of transposons.

Required for the last steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.

Gene Information

Human
Gene Name:	TDRKH
Uniprot:	Q9Y2W6
Entrez:	11022

Family

Belongs to:

Tdrkh family

Alternative Names

TDRD2; TDRKH; tudor and KH domain containing; tudor and KH domain-containing protein

Molecular Weight

Mass (kDA):
62.046 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (151769433..151790534, complement)

Subcellular Localizations

Cytoplasm. Mitochondrion. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline.

Diseases

Muscular Atrophy
Steroid Sulfatase Deficiency Disease
Atrophy
Spinal Muscular Atrophy

Pathways

Methylation
Rna Processing
Localization

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TDRKH

References

PMID: 10767542 by Lamb F.S., et al. Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains.

PMID: 25621951 by Cunningham C.N., et al. USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.