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- Table of Contents
Facts about Ras-related protein Rab-26.
Mediates transportation of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach.
Human | |
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Gene Name: | RAB26 |
Uniprot: | Q9ULW5 |
Entrez: | 25837 |
Belongs to: |
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small GTPase superfamily |
RAB26, member RAS oncogene family; Ras-related oncogene protein; ras-related protein Rab-26; V46133
Mass (kDA):
27.9 kDA
Human | |
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Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (2148144..2154165) |
Predominantly expressed in brain.
Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.
PMID: 11043516 by Seki N., et al. cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP- binding protein on chromosome 16p13.3 region.
PMID: 20038531 by Tian X., et al. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.