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- Table of Contents
Facts about Ras-related protein Rab-14.
May act by regulating the kinesin KIF16B-cargo institution to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion.
Human | |
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Gene Name: | RAB14 |
Uniprot: | P61106 |
Entrez: | 51552 |
Belongs to: |
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small GTPase superfamily |
bA165P4.3 (member RAS oncogene family); F protein-binding protein 1; FBP; RAB-14; RAB14, member RAS oncogene family; ras-related protein Rab-14; small GTP binding protein RAB14
Mass (kDA):
23.897 kDA
Human | |
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Location: | 9q33.2 |
Sequence: | 9; NC_000009.12 (121178133..121201869, complement) |
Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
PMID: 16962593 by Proikas-Cezanne T., et al. Rab14 is part of the early endosomal clathrin-coated TGN microdomain.
PMID: 21255211 by Seto S., et al. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.