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- Table of Contents
3 Q&As
Facts about Rab11 family-interacting protein 3.
Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.
Human | |
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Gene Name: | RAB11FIP3 |
Uniprot: | O75154 |
Entrez: | 9727 |
Belongs to: |
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No superfamily |
ARFO1; Arfophilin-1; EF hands-containing Rab-interacting protein; eferin; FIP3-Rab11; KIAA0665arfophilin-1; MU-MB-17.148; PAC196A12.1; RAB11 family interacting protein 3 (class II); rab11-family interacting protein 3; Rab11-FIP3rab11 family-interacting protein 3
Mass (kDA):
82.44 kDA
Human | |
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Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (425621..523011) |
Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission (PubMed:15158446, PubMed:15601896, PubMed:18511905). Interaction with Rab11 mediates localization to endosomes (PubMed:11495908). Interaction with ARF6 mediates
PMID: 11481332 by Prekeris R., et al. Identification of a novel Rab11/25 binding domain present in eferin and rip proteins.
PMID: 12800201 by Behrends U., et al. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.