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RAB11A Antibodies
AND RAB11A ELISA kits, RAB11A Proteins
Many biological assays use antibodies to detect RAB11A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB11A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB11A antibodies...
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RAB11A Infographic by Boster Bio
All RAB11A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA2282
100 μg/vial
Cat # PA2282
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01436-2
100 μg/vial
Cat # M01436-2
100 μg/vial
RAB11A Overview
Facts about Ras-related protein Rab-11A.
Ras-related protein Rab-11A (RAB11A)
The little GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their combination with membranes. Rabs cycle between an inactive GDP-bound form and an energetic GTP-bound form that's able to recruit to membranes distinct set of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.
This Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB11A |
| Uniprot: | P62491 |
| Entrez: | 8766 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
MGC1490; RAB 11A, member oncogene family; RAB11; Rab-11; Rab11A; RAB11A, member RAS oncogene family; YL8; YL8ras-related protein Rab-11A
Molecular Weight
Mass (kDA):
24.394 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q22.31 |
| Sequence: | 15; NC_000015.10 (65869491..65891989) |
Subcellular Localizations
Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Diseases
- Carcinoma
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Hiv Infections
- Melanoma
- Cystic Fibrosis
- Cell Invasion
- Fibrosis
- Cholestasis
- Immunologic Deficiency Syndromes
- Esophageal Neoplasms
Interacting Proteins
- CHMP1B
- EVI5
- RAB11FIP2
- RAB11FIP5
- YAP1
- ZFYVE27
Pathways
- Transport
- Localization
- Endocytosis
- Secretion
- Transcytosis
- Endocytic Recycling
- Cytokinesis
- Exocytosis
- Receptor Recycling
- Cell Cycle
- Clathrin-mediated Endocytosis
- Secretory Pathway
- Intracellular Transport
PTMs
- Phosphorylation
- Biotinylation
- Prenylation
- Geranylgeranylation
- Palmitoylation
Research Areas
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB11A
bosterbio.com/bosterbio-gene-info-cards/RAB11A
References
PMID: 1704119 by Drivas G.T., et al. Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.
PMID: 9662449 by Gromov P.S., et al. Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins.