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- Table of Contents
Facts about Ras-related protein Rab-10.
That Rab is mostly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane.
Human | |
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Gene Name: | RAB10 |
Uniprot: | P61026 |
Entrez: | 10890 |
Belongs to: |
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small GTPase superfamily |
GTP-binding protein RAB10; RAB10, member RAS oncogene family; ras-related GTP-binding protein; ras-related protein Rab-10
Mass (kDA):
22.541 kDA
Human | |
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Location: | 2p23.3 |
Sequence: | 2; NC_000002.12 (26034084..26137454) |
Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasm, cytoskeleton, cilium basal body. Endoplasmic reticulum membrane. Cytoplasm, perinuclear region. Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (PubMed:20576682, PubMed:30398148). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulu
PMID: 12450215 by He H., et al. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues.
PMID: 16641372 by Babbey C.M., et al. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells.