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PPARGC1A Antibodies
AND PPARGC1A ELISA kits, PPARGC1A Proteins
Many biological assays use antibodies to detect PPARGC1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPARGC1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPARGC1A antibodies...
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PPARGC1A Infographic by Boster Bio
All PPARGC1A Products
Product
Figures
Specificity
Applications
Price
Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody
1 Citations 4 Q&As
Human, Mouse, Rat
WB
$370
Cat # M00236
100 μl
Cat # M00236
100 μl
PPARGC1A Overview
Facts about Peroxisome proliferator-activated receptor gamma coactivator 1-alpha.
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can modulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.
Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a large variety of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 from the skeletal muscle in an ESRRA-dependent Method.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPARGC1A |
| Uniprot: | Q9UBK2 |
| Entrez: | 10891 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
LEM6; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC1 alpha; PGC1A; PGC-1-alpha; PGC1APGC-1(alpha); PGC1peroxisome proliferative activated receptor, gamma, coactivator 1; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC1A; PPARGC-1-alpha; PPARGC1PGC-1v
Molecular Weight
Mass (kDA):
91.027 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p15.2 |
| Sequence: | 4; NC_000004.12 (23792021..24472905, complement) |
Tissue Specificity
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
Subcellular Localizations
[Isoform 1]: Nucleus. Nucleus, PML body.; [Isoform B4]: Nucleus.; [Isoform B4-8a]: Cytoplasm. Nucleus.; [Isoform B5]: Nucleus. Nucleus, PML body.; [Isoform 9]: Nucleus.
Diseases
- Diabetes Mellitus
- Obesity
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Insulin Sensitivity
- Metabolic Diseases
- Inflammation
- Heart Failure
- Neurodegenerative Disorders
- Hyperglycemia
- Malignant Neoplasms
- Hypertrophy
- Huntington Disease
Interacting Proteins
- ESRRA
- ESRRG
- HNF4A
- LRPPRC
- PPARG
Pathways
- Fatty Acid Oxidation
- Gluconeogenesis
- Oxidative Phosphorylation
- Pathogenesis
- Transport
- Energy Homeostasis
- Glucose Homeostasis
- Secretion
- Aging
- Cell Death
- Localization
- Angiogenesis
- Lipid Oxidation
PTMs
- Phosphorylation
- Oxidation
- Deacetylation
- Acetylation
- Methylation
- Dephosphorylation
Research Areas
- Alzheimers Research
- Cancer
- Cholesterol Metabolism
- Chromatin Research
- Diabetes Research
- Epigenetics
- Lipid and Metabolism
- Mitochondrial-Mediated Pathway
- mTOR Pathway
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPARGC1A
bosterbio.com/bosterbio-gene-info-cards/PPARGC1A
References
PMID: 10585775 by Esterbauer H., et al. Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.
PMID: 10643692 by Larrouy D., et al. Cloning and mRNA tissue distribution of human PPARgamma coactivator- 1.
1 Publications of Boster PPARGC1A Antibodies & ELISA Kits
- PubMed ID: 10.3390/ijms20246128, Expression and Secretion of an Atrial Natriuretic Peptide in Beige-Like 3T3-L1 A...
*More publications can be found for each product on its corresponding product page