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- Table of Contents
Facts about Queuine tRNA-ribosyltransferase catalytic subunit 1.
The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active website deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity).
Mouse | |
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Gene Name: | Qtrt1 |
Uniprot: | Q9JMA2 |
Entrez: | 60507 |
Belongs to: |
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queuine tRNA-ribosyltransferase family |
EC 2.4.2.29; Guanine insertion enzyme; queuine tRNA-ribosyltransferase 1; queuine tRNA-ribosyltransferase; TGTFP3235; TGUT; tRNA-guanine transglycosylase
Mass (kDA):
44.093 kDA
Mouse | |
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Location: | 9|9 A3 |
Sequence: | 9; |
Expressed in brain, heart, kidney, liver, ling, skeletal muscle, spleen and testis.
PMID: 19414587 by Boland C., et al. Queuosine formation in eukaryotic tRNA occurs via a mitochondria- localized heteromeric transglycosylase.
PMID: 29862811 by Behrens C., et al. Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase.