Prolactin receptor Antibodies

Prolactin receptor (PRLR)

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival element for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase stimulation and activation of AKT.

Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Gene Information

Human
Gene Name:	PRLR
Uniprot:	P16471
Entrez:	5618

Family

Belongs to:
type I cytokine receptor family

Alternative Names

delta 4-delta 7/11 truncated prolactin receptor; delta 4-SF1b truncated prolactin receptor; hPRL receptor; hPRLrI; PRLR; PRL-R; Prolactin R; prolactin receptor delta 7/11; prolactin receptor; ProlactinR; secreted prolactin binding protein

Molecular Weight

Mass (kDA):
69.506 kDA

Genomic Context

Human
Location:	5p13.2
Sequence:	5; NC_000005.10 (35048756..35230724, complement)

Tissue Specificity

Expressed in breast, placenta, kidney, liver and pancreas.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.; [Isoform 7]: Secreted.

Diseases

• Malignant Neoplasms
• Pituitary Diseases
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Neoplasms
• Carcinoma
• Janiceps
• Cell Transformation, Neoplastic
• Lymphoma
• Infertility
• Malignant Paraganglionic Neoplasm
• Mammary Neoplasms, Experimental
• Hyperprolactinemia

• Adenocarcinoma
• Malignant Neoplasm Of Prostate
• Endometrial Polyp
• Carcinogenesis
• Nervousness
• Insulin Resistance
• Neoplasm Metastasis

Interacting Proteins

• PRL
• YWHAZ

Pathways

• Lactation
• Secretion
• Cell Proliferation
• Localization
• Gland Development
• Pathogenesis
• Mammary Gland Development
• Ovulation
• Cell Growth
• Reverse Transcription
• Embryo Implantation
• Transport
• Cell Differentiation

• Parturition
• Adipose Tissue Development
• Fertilization
• Hair Cycle
• Angiogenesis
• Glucose Homeostasis
• Tissue Development

PTMs

• Phosphorylation
• Glycosylation
• Cleavage
• Dephosphorylation
• Deglycosylation

• Ubiquitination
• Biotinylation
• Reduction
• Deacetylation
• Acetylation

Research Areas

• Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRLR

Best Uses Of The PRLR Marker From Boster Bio

The Boster Bio Anti-Prolactin receptor/PRLR marker might be the best choice for you if you are looking for an PRLR anti-body. This antibody was validated by Boster Bio using known positive and negative samples. Its high affinity and specificity make it a great option for any research project. Boster provides multiple validation platforms , and rewards early reviewers with product credits. Boster offers rewards to all scientists across the world and also rewards the first reviewers.

Boster Bio Anti-Prolactin Receptor/PRLR Marker

The Boster Bio Anti-ProlactinReceptor/PRLR Marker recognizes the human PRL receptor, and is validated with positive and negative control samples. Boster's PRL antibodies were tested using the Rat, Mouse, and Human. Boster has an excellent track record of developing highly specific antibodies for the PRLR, and they provide first reviewers with product credits.

PRLR and E2 have synergistic effects on prolactinoma cell lines. E2 stimulated prolactinoma cell growth and increased PRLR expression, while decreasing D2R. PRL increased pERa but decreased D2R. However, when used in isolation the anti-prolactin drugs did not cause any obvious changes in D2R expression.

Boster's high-affinity prima antibodies

Boster Bio has a wide range of validated antibodies, ELISA kit kits, as well as other Reagents. The reagents and antibodies are manufactured in-house and adhere to strict quality standards. Customers can buy primary antibodies and ELISA kit for a variety applications that include IHC and WB. The Boster Lab also makes ELISA controls and kits that have been subject to rigorous quality assurances.

Apart from producing monoclonal antibodies Boster also makes polyclonal antibody that target a variety of immunoglobulins. Its technology has helped researchers to create antibodies that target a variety of biological processes and disease mechanisms. The company's high affinity primary antibodies make use of the PRLR marker to recognize a wide range of immune system proteins. Its antibody portfolio also includes a growing variety of monoclonal and polyclonal antibodies.

These antibodies are able to recognize two distinct antigens in the same tissue section either simultaneously or in succession. The visualization of one antigen is not hindered by the pigments used to visualize it. The optical filter combination however, can be used to distinguish both primary and secondary antibodies. High-affinity antibodies are highly sensitive but require further optimization. Boster's high affinity primary antibodies are constructed using the PRLR marker to minimize cross-reactivity.

Boster's high affinity primary antibody utilizes the PRLR marker. This makes it more sensitive and precise than ever before. Its high specificity and affinity make it an ideal tool for measuring specific analytes in the simplest formulations. Boster's catalog has a complete range of primary ELISA kits and antibodies. To make an informed choice you can select from a range of choices based on your specific requirements.

Boster's validated antibodies on WB, IHC

Boster has the right solution when you're in the market for an appropriate anti-body to use in your research project, or would like to utilize ELISA to test your reagents efficiently. As a leader in the production of immunological reagents Boster offers more than 12,000 antibodies, including WB and IHC-validated products. The antibodies are rigorously tested for sensitivity as well as affinity against a range of untransfected and tissue lines.

While WB is a crucial validation tool, it does have certain limitations. WB results can be misleading, for instance antibodies can show up in multiple bands that are not relevant to the target cell type. It is important to verify the results in such instances. Boster's validation process can ensure that your antibodies are dependable for immunostaining and Western blotting.

Boster employs two siRNA probes per target for validation. Two siRNA probes can be added during the process of immunoblotting. Both probes need to be silencing of at least 50% of the target protein. These factors can significantly impact the reproducibility of results. Therefore, it is crucial to conduct a thorough validation of antibodies prior to using any antibodies in research. Before using an antibody in your experiments, it is important to know its limitations.

Boster's ICC

Boster Bio's ICC and PRLR Marker were validated on a variety of platforms using positive and unpublished samples. Boster's ICC and PRLR Marker was developed for the detection of both prolactin isoforms. This product was validated by their high affinity and specificity. The ICC/PRLR Marker awards product credits to the first reviewers. Boster's ICC/PRLR Marker has long been used by scientists around the world for years.

Boster's Immunofluorescence

In immunofluorescence tests, antibodies bind to a fluorescent dye to detect the target molecule. It is widely used in clinical immunology laboratories for diagnosis and monitoring the treatment of patients. This technique is similar to immunohistochemistry, but uses a tissue section as the antigenic source. It relies on the presence of autoantibodies, that are created in response to native autoantigens in fixed cells.

FITC-labeled antibodies can be used to detect M. tuberculosis. They were added to the suspension of 25 mg/l. tuberculosis in PBS. The sample was washed three times in PBS and then placed on a glass slide. The slide was processed using IHC. The resultant images were then analyzed in ImageJ software.

t-CyCIF is a color-changing immunofluorescence imaging system that has been developed. Repetitive staining of slides has been around for years. The technique involved the removal of antibodies using denaturants. However, Gerdes et al. Gerdes and colleagues. (2013) reported chemical inactivation (fluorophores being inactivated) after several immunofluorescence cycles. By using the t–CyCIF method t–CyCIF offers many benefits over the current methods.

The Boster's Immunofluorescence method makes use of fluorescent nanoparticles injectable with anti-M. tuberculosis antigens. These antibodies produce bright fluorescence in samples stained. This is consistent with high levels of biomolecules. Researchers believe that the A-nanoparticle conjugates for protein are able to interact with other surface molecules of bacteria.

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