Porcn Antibodies

AND Porcn ELISA kits, Porcn Proteins

Many biological assays use antibodies to detect Porcn, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Porcn in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Porcn antibodies...

We validate the specificity of these antibodies to Porcn by testing them on tissues known to express Porcn positively and negatively. Browse below to find the Porcn antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Porcn Infographic by Boster Bio

All Porcn Products

Product

Figures

Specificity

Applications

Price

Anti-PORCN Antibody

Mouse, Rat

$405
Cat # A03268
100ul

PORCN (NM_203473) Human Over-expression Lysate

Human

$628
Cat # LS064840
100 µg

Porcn Overview

Facts about Protein-serine O-palmitoleoyltransferase porcupine.

Protein-serine O-palmitoleoyltransferase porcupine (Porcn)

Protein-serine O-palmitoleoyltransferase that serves as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.

Gene Information

Mouse
Gene Name:	Porcn
Uniprot:	Q9JJJ7
Entrez:	53627

Family

Belongs to:

membrane-bound acyltransferase family

Alternative Names

2410004O13Rik; DHOF; EC 2.3.1.-; FODH; MG61PPNprobable protein-cysteine N-palmitoyltransferase porcupine; por; PORCMGC29687; porcupine homolog (Drosophila); Protein MG61

Molecular Weight

Mass (kDA):
52.508 kDA

Genomic Context


Mouse

Location:	X A1.1\|X 3.7 cM
Sequence:	X;

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. Isoform 4 is strongly expressed in kidney, liver, lung, spleen and testis. Isoform 1 is strongly expressed in brain, heart and muscle and poorly in kidney, liver, lung, spleen and testis.

Diseases

Focal Dermal Hypoplasia
Hypoplasia
Embryonic Mosaic
Malignant Neoplasms
Neoplasms
Syndactyly
Hemangioma
Angioma Serpiginosum
Carcinoma
Congenital Abnormality
Atrophy
Pentalogy Of Cantrell
Hernia

Cell Transformation, Neoplastic
Developmental Disabilities
Microphthalmos
Limb Defect
Dysplasia
Mammary Neoplasms
Multisystem Disorder

Pathways

Secretion
Cell Proliferation
Gastrulation
Tissue Development
Pathogenesis
Tissue Homeostasis
Transport
Cell Adhesion
Secretory Pathway
Convergent Extension
Dna Hypomethylation
Signal Transmission
Stem Cell Maintenance

Dna Methylation
Localization
Embryo Development
Methylation
Regeneration
Lipid Modification
Tissue Regeneration

PTMs

Acylation
Palmitoylation

Phosphorylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Porcn

References

PMID: 10866835 by Tanaka K., et al. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

PMID: 12842094 by Tanaka K., et al. Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embryonic carcinoma cells.