PLA2G2A Antibodies

Phospholipase A2, membrane associated (PLA2G2A)

Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis.

Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877).

Gene Information

Human
Gene Name:	PLA2G2A
Uniprot:	P14555
Entrez:	5320

Family

Belongs to:
phospholipase A2 family

Alternative Names

EC 3.1.1.4; GIIC sPLA2; Group IIA phospholipase A2; Mom1; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); phospholipase A2, membrane associated; PLA2B; PLA2BPLA2; PLA2G2A; PLA2L; PLA2LPLA2S; PLAS1; RASF-A; sPLA2

Molecular Weight

Mass (kDA):
16.083 kDA

Genomic Context

Human
Location:	1p36.13
Sequence:	1; NC_000001.11 (19975431..19980434, complement)

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Secreted.

Diseases

• Neoplasms
• Malignant Neoplasms
• Inflammation
• Cell Transformation, Neoplastic
• Adenoma
• Intestinal Neoplasms
• Polyposis
• Adenomatous Polyposis Coli
• Colorectal Cancer
• Carcinoma
• Colorectal Neoplasms
• Colonic Neoplasms
• Carcinogenesis

• Adenocarcinoma
• Malignant Tumor Of Colon
• Polyps
• Atherosclerosis
• Stomach Neoplasms
• Diabetes Mellitus
• Malignant Neoplasm Of Stomach

Interacting Proteins

• ITGB3

Pathways

• Cell Proliferation
• Pathogenesis
• Localization
• Immune Response
• Inflammatory Response
• Cell Differentiation
• Dna Repair
• Cell Growth
• Secretion
• Cell Cycle
• Macropinocytosis
• Autophagy
• Keratinization

• Osteoclast Differentiation
• Cell Activation
• Cell Migration
• Dna Hypermethylation
• Gene Silencing
• B Cell Activation
• Chondrocyte Differentiation

PTMs

• Phosphorylation
• Cleavage

• Oxidation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLA2G2A

Best Uses Of The PLA2G2A Marker

This article will help you learn more about the Anti-Secretogranin 3/SCG3 Antibody and the PLA2G2A marker. This article will also help you to choose the best marker and provide gene infographics. It is easy and straightforward to determine which anti–Secretogranin 3/SCG3Antibody is best for you research.

Boster Bio's Anti-Secretogranin 3/SCG3 Antibody

PLA2G2A marks are used to detect a wide range of ocular disease. This marker is used to detect a number of diseases such as Stargardt syndrome, Stargardt Disease, Choroidermia and Cone-rod Dystrophy.

Boster Bio's AntiPLA2G2A Marker

The anti–PLA2G2A mark can detect genes characteristic of dysfunctional immuno cells. The markers include IL33, OLFM1, KLRC2, PTPN3, SDC1, TNFSF9, VLDLR, and PTPN4. TNFSF9 is, IL10RA and CTLA2A can be detected using the gene expression signature.