PIGR Antibodies

Polymeric immunoglobulin receptor (PIGR)

This receptor binds polymeric IgA and IgM in the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted in the apical surface.

During this process a cleavage occurs that divides the extracellular (known as the secretory component) in the transmembrane segment. .

Gene Information

Human
Gene Name:	PIGR
Uniprot:	P01833
Entrez:	5284

Family

Belongs to:
No superfamily

Alternative Names

FLJ22667; Free Secretory Component (FSC) ; hepatocellular carcinoma associated protein TB6; Hepatocellular carcinoma-associated protein TB6; MGC125361; MGC125362; pIgA-Secretory Component Complex; pIgM-Secretory Component Complex; pIgR; Poly-Ig receptor; polymeric immunoglobulin receptor; Secretory Component (SC); sIgA-Secretory Component Complex

Molecular Weight

Mass (kDA):
83.284 kDA

Genomic Context

Human
Location:	1q32.1
Sequence:	1; NC_000001.11 (206928522..206946466, complement)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.; [Secretory component]: Secreted.

Diseases

• Malignant Neoplasms
• Carcinoma
• Colorectal Cancer
• Adenoma
• Malignant Tumor Of Colon
• Neoplasms
• Impacted Tooth
• Colorectal Neoplasms
• Inflammation
• Malignant Squamous Cell Neoplasm
• Cattle Diseases
• Stomach Neoplasms

• Inflammatory Bowel Diseases
• Lung Diseases
• Neoplasm Invasiveness
• Intestinal Diseases
• Lung Diseases, Obstructive
• Dysplasia
• Fibrosis

Pathways

• Transport
• Localization
• Transcytosis
• Pathogenesis
• Chromosome Localization
• Complement Activation
• Hypersensitivity
• Metaphase
• Disease Resistance
• Transepithelial Transport

• Regeneration
• Translation
• Liver Regeneration
• Fatty Acid Oxidation
• Secretion

PTMs

• Glycosylation

• Acetylation

• Oxidation

Research Areas

• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIGR

Boster Bio - Best Uses Of The PIGR Marker

Boster Bio offers a lot of DNA markers. Boster bio offers many advantages to DNA markers, such as a guide explaining how to use it, and troubleshooting tips that will assist you in analyzing your results. These are just a few examples of Boster Bio-compatible experiments. These DNA markers have many uses. They're also great tools for gene therapy, tissue cultures, and genetics research.

Boster Bio Anti–CD8 C–D–Lanthan–CD8a Monoclonal Antibody

This boster bio antibody is a monoclonal anti-human CD8a antibody that has been pre-tested and validated. It can stain one to two million cells per mL. It can be stored at between 2 and 8 degrees Celsius. It can also be stored at room temperatures for long-term storage.

The anti-CD8 molecule is composed of two chains. This antigen is expressed on the surface of various cell types, including thymocytes and natural killer cells. These cells are capable and capable of recognizing foreign substances as dangerous or beneficial. The bone marrow cells as well as thymocytes recognize this antigen.

The Bio-Rad porcine antigen collection includes monoclonal antibody, recombinant cell cytokine proteins and immunomodulators. It also includes alterations in immune responses induced by pathogens. Biomarker expression maps can further help to define the porcine immuno cell population.

The PIGR (or polymeric IgR), is responsible to convert pentameric IgA from secreted IgA into secreted IgA. These two types are distinct, with the former granting immunity effector function and the latter possessing antigen-specific receptors.

Boster Bio Anti CD5 (Mantle Cell Lymphoma marker) Monoclonal Antibody

Boster Bio Anti CD5 Monocleolal antibody reacts with Bovine (Chicken, Guinea Pig), Human, Monkey and Rabbit. It has been used for the detection of this marker since 1950. It is a transmembrane 67 kDa protein that is expressed by 95% and 72% respectively of peripheral blood lymphocytes and thymocytes. It is a useful marker as it interacts with a variety neoplastic T and B cells.

Nanoprobes are useful tools to identify tumor cells or mantle cell lymphoma. They are created by selectively oxidizing double bond in oleateligands on nanoparticles. The nanoprobes are used to couple monoclonal antibody targeting CD5 or CD20. They recognize tumor cells and kill cancer cells.

This fusion vaccine eliminates immunity to self-antigens related to angiogenesis. This fusion protein was synthesized by fusing mature b-defensin 2 with an extracellular segment of Vascular Endothelial Cadherin. In addition, the vaccine's ligand-binding activity was measured using an alginate-encapsulated tumour cell assay.

Mantle-cell lymphoma is a heterogeneous disorder that remains incurable despite current chemotherapy. Monoclonal antibody therapy is a significant advancement in immunotherapeutic strategies. However, it has been limited by poor efficacy and off-target toxicities as well as drug resistance. These issues have forced the development of novel mAbs that can improve their target specificity. Monoclonal antibody therapy is an important tool in many areas of cancer research and treatment.

MBC and MBC-M cell responses to different antigens were revealed by a molecular analysis. They also have different dynamics in GC production and entry. They have a lower mutation rate than their CSR counterparts. They also show high cross-reactivity. These cells also secrete IgG antibodies that are different from CSR counterparts. The anti-CD5 antibody is a great choice.

Scientists can submit results using this antibody from special species, applications, and samples. You will receive product credit for your research. This applies to all scientists around world, regardless if they are from the same country. It is available from several reputable suppliers and has high quality and value. It is also very affordable. Don't wait! BosterBio Anti-CD5 Monoclonal antibody is available today!

MBCs' polymeric Ig receptor helps them fight a variety of infections. The IgM antibodies in the human MBC M are directed at Mucus-embedded SIgA co-infected commensals. It aids the immune system in fighting pathogenic bacteria. These MBCs can be a good source of anti CD5 antibodies because they are so diverse.

Boster Bio Anti CD5 Monocolonal Antibody (Mantel Cell LymphomaMarker) is made from a purified CD5 Recombinant Protein and complete Freund's adjuvant Emulsification. This antibody is safe for immunotherapy and other medical research. So, get yours today and fight cancer in a new way!

Monoclonal antibodies can be used to treat mantle cell lymphoma. Its main advantage is its ability to target tumor-specific immune cells. This antibody also blocks cyclindependent kinase. Another important cancer marker is also blocked. Despite its small size this antibody can be a valuable tool to fight this cancer.

Second-generation anti-CD20 mAbs can overcome resistance more efficiently. Ofatumumab was isolated from transgenic mice and binds to a distinct CD20 epitope. These second-generation antibodies bind to small and big extracellular loops. They also stimulate the release and activation of apoptotic substances.