PIK3C2A Antibodies

AND PIK3C2A ELISA kits, PIK3C2A Proteins

Many biological assays use antibodies to detect PIK3C2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3C2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3C2A antibodies...

We validate the specificity of these antibodies to PIK3C2A by testing them on tissues known to express PIK3C2A positively and negatively. Browse below to find the PIK3C2A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PIK3C2A Infographic by Boster Bio

All PIK3C2A Products

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Specificity

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Price

Anti-PIK3C2A Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A03530
100ul

Anti-PI 3 Kinase Class 2A (PIK3C2A) Mouse Monoclonal Antibody [Clone ID: OTI3H2]

Human, Mouse, Rat

IHC, WB

$523
Cat # M03530
100 µl

PI 3 Kinase Class 2A (PIK3C2A) (NM_002645) Human Over-expression Lysate

Human

$960
Cat # LS005286
100 µg

PIK3C2A Overview

Facts about Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha.

PIK3C2A 3D structure. Source: alphafold

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as instant messengers. Has a role in many intracellular trafficking events.

Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 into the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation.

Gene Information

Human
Gene Name:	PIK3C2A
Uniprot:	O00443
Entrez:	5286

Family

Belongs to:

PI3/PI4-kinase family

Alternative Names

C2-containing phosphatidylinositol kinase; CPK; DKFZp686L193; EC 2.7.1; EC 2.7.1.154; MGC142218; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; Phosphoinositide 3-kinase-C2-alpha; phosphoinositide-3-kinase, class 2, alpha polypeptide; PI3-K-C2(ALPHA); PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PtdIns-3-kinase C2 subunit alpha

Molecular Weight

Mass (kDA):
190.68 kDA

Genomic Context


Human

Location:	11p15.1
Sequence:	11; NC_000011.10 (17086575..17207986, complement)

Tissue Specificity

Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals.

Subcellular Localizations

Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566).

Diseases

Malignant Neoplasms
Sclerosis
Learning Disorders
Neoplasm Metastasis
Metastatic Malignant Neoplasm To The Lymph Node
Insulinoma
Neurodegenerative Disorders
Diphtheria
Carcinoma
Carcinogenesis
Glomerulonephritis
Mouth Neoplasms

Neoplasms
Nervousness
Memory Impairment
Colorectal Cancer
Malignant Neoplasm Of Prostate
Malignant Squamous Cell Neoplasm
Cell Transformation, Neoplastic

Pathways

Immune Response
Cell Growth
Insulin Secretion
Proteolysis
Endocytosis
Glomerular Filtration
Methylation
System Development
Cell Cycle
Nervous System Development

Cell Differentiation
Cell Communication
Pathogenesis
Exocytosis
Secretion

PTMs

Phosphorylation

Methylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3C2A

References

PMID: 9337861 by Domin J., et al. Cloning of a human phosphoinositide 3-kinase with a C2 domain which displays reduced sensitivity to the inhibitor wortmannin.

PMID: 10766823 by Domin J., et al. The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.