This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
PELP1 Antibodies
AND PELP1 ELISA kits, PELP1 Proteins
Many biological assays use antibodies to detect PELP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PELP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PELP1 antibodies...
Previous: SEPTIN9
Next: Nit1
PELP1 Infographic by Boster Bio
All PELP1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02530
100 μl
Cat # M02530
100 μl
PELP1 Overview
Facts about Proline-, glutamic acid- and leucine-rich protein 1.
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1)
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic action when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner.
Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. May have important functional implications in ER/growth variable cross-talk.
Gene Information
| Human | |
|---|---|
| Gene Name: | PELP1 |
| Uniprot: | Q8IZL8 |
| Entrez: | 27043 |
Family
| Belongs to: |
|---|
| RIX1/PELP1 family |
Alternative Names
HMX3; MNARmodulator of nongenomic activity of estrogen receptor; Modulator of non-genomic activity of estrogen receptor; P160; proline and glutamic acid rich nuclear protein; proline, glutamate and leucine rich protein 1; proline, glutamic acid and leucine rich protein 1; proline-, glutamic acid- and leucine-rich protein 1; proline-, glutamic acid-, leucine-rich protein 1; Transcription factor HMX3
Molecular Weight
Mass (kDA):
119.7 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.2 |
| Sequence: | 17; NC_000017.11 (4669774..4704137, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Cytoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors (PubMed:16140940).
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Neoplasms, Hormone-dependent
- Tumor Progression
- Ductal Carcinoma
- Ductal Breast Carcinoma
Interacting Proteins
- H3F3A
- KDM1A
- MDN1
- NFKB1
- NPM1
- SENP3
- SUMO2
- WDR18
Pathways
- Localization
- Cell Proliferation
- Cell Cycle
- Oncogenesis
- Chromatin Remodeling
- Ribosome Biogenesis
- Cell Growth
- Rna Interference
- Cell Migration
- Receptor Transactivation
- Methylation
- Neuroprotection
- Autophagy
PTMs
- Phosphorylation
- Acetylation
- Sumoylation
Research Areas
- Cellular Markers
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PELP1
bosterbio.com/bosterbio-gene-info-cards/PELP1
References
PMID: 12415108 by Wong C.-W., et al. Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
PMID: 11481323 by Vadlamudi R.K., et al. Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.