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Pcsk9 Antibodies
AND Pcsk9 ELISA kits, Pcsk9 Proteins
Many biological assays use antibodies to detect Pcsk9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pcsk9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pcsk9 antibodies...
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Pcsk9 Infographic by Boster Bio
All Pcsk9 Products
Product
Figures
Specificity
Applications
Price
Human PCSK9/Proprotein Convertase 9 ELISA Kit PicoKine®
5 Citations 9 Q&As
Human
ELISA
$499
Cat # EK1147
96 wells/kit, with removable strips.
Cat # EK1147
96 wells/kit, with removable strips.
Mouse PCSK9/Proprotein Convertase 9 ELISA Kit PicoKine®
2 Citations 10 Q&As
Mouse
ELISA
$499
Cat # EK1148
96 wells/kit, with removable strips.
Cat # EK1148
96 wells/kit, with removable strips.
Human
IP, WB
$370
Cat # M00085
100 μl
Cat # M00085
100 μl
Human
$250
Cat # PROTQ8NBP7
2ug, 10ug, 1mg
Cat # PROTQ8NBP7
2ug, 10ug, 1mg
Rat PCSK9 ELISA Kit PicoKine®
11 Q&As
Rat
ELISA
$499
Cat # EK1701
96 wells/kit, with removable strips.
Cat # EK1701
96 wells/kit, with removable strips.
Human
ELISA
$500
Cat # EZ1147
For 5 plates, 96 wells each
Cat # EZ1147
For 5 plates, 96 wells each
Cynomolgus monkey, Human, Mouse
ELISA, Flow Cytometry, FTA
$349
Cat # M00085-3
100 μg
Cat # M00085-3
100 μg
Pcsk9 Overview
Facts about Proprotein convertase subtilisin/kexin type 9.
Proprotein convertase subtilisin/kexin type 9 (Pcsk9)
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.
Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May stop the recycling of LDLR from endosomes to the cell surface or guide it to lysosomes for degradation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pcsk9 |
| Uniprot: | Q80W65 |
| Entrez: | 100102 |
Family
| Belongs to: |
|---|
| peptidase S8 family |
Alternative Names
EC 3.4.21; EC 3.4.21.111; FH3; FH3neural apoptosis regulated convertase 1; FHCL3; HCHOLA3; hypercholesterolemia, autosomal dominant 3; LDLCQ1; NARC1; NARC-1; NARC-1convertase subtilisin/kexin type 9 preproprotein; NARC1EC 3.4.21.-; Neural apoptosis-regulated convertase 1; PC9; PCSK9; Proprotein Convertase 9; proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9
Molecular Weight
Mass (kDA):
74.823 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4|4 C7 |
| Sequence: | 4; |
Tissue Specificity
Hepatocytes, kidney mesenchymal cells, intestinal ileum, colon epithelia and embryonic brain telencephalon neurons.
Diseases
- Hypercholesterolemia
- Hypercholesterolemia, Familial
- Hyperlipoproteinemia Type Iib
- Heart Diseases
- Coronary Heart Disease
- Atherosclerosis
- Hyperlipoproteinemia Type Iia
- Cardiovascular Diseases
- Dyslipidemias
- Hypocholesterolemia
- Diabetes Mellitus
- Coronary Artery Disease
- Hyperlipidemia
Pathways
- Secretion
- Cholesterol Homeostasis
- Endocytosis
- Localization
- Transport
- Proteolysis
- Response To Statin
- Lipid Homeostasis
- Pathogenesis
- Translation
- Rna Interference
- Receptor-mediated Endocytosis
- Secretory Pathway
PTMs
- Cleavage
- Ubiquitination
- Phosphorylation
- Acetylation
Research Areas
- Cholesterol Metabolism
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pcsk9
bosterbio.com/bosterbio-gene-info-cards/Pcsk9
References
PMID: 12897189 by Maxwell K.N., et al. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice.
PMID: 12552133 by Seidah N.G., et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
7 Publications of Boster Pcsk9 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fphys.2021.593862, Impact of PCSK9 on CTRP9-Induced Metabolic Effects in Adult Rat Cardiomyocytes
- PubMed ID: 10.2147/DMSO.S234243, Is PCSK9 Associated with Plasma Lipid Levels in a Sub-Saharan African Population...
- PubMed ID: 10.1161/ATVBAHA.117.310656, RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells Fr...
- PubMed ID: 10.1016/j.ymthe.2019.03.003, Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Viv...
- PubMed ID: 10.1016/j.metabol.2017.07.006, Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating ...
- PubMed ID: 29449334 , RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells Fr...
- PubMed ID: 28987238 , Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating ...
*More publications can be found for each product on its corresponding product page