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Padi4 Antibodies
AND Padi4 ELISA kits, Padi4 Proteins
Many biological assays use antibodies to detect Padi4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Padi4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Padi4 antibodies...
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Padi4 Infographic by Boster Bio
All Padi4 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M01353
100 µl
Cat # M01353
100 µl
Padi4 Overview
Facts about Protein-arginine deiminase type-4.
Protein-arginine deiminase type-4 (Padi4)
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 in'Arg-54' (to form H1R54ci), histone H3 in'Arg-2','Arg-8','Arg-17' or'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 in'Arg-3' (to form H4R3ci).
Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of'Arg- 54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and international chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Padi4 |
| Uniprot: | Q9Z183 |
| Entrez: | 18602 |
Family
| Belongs to: |
|---|
| protein arginine deiminase family |
Alternative Names
HL-60 PAD; PAD; PAD4; PADI4; PADI5PADI-H protein; PADPAD4; PDI4; PDI5EC 3.5.3.15; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV; protein-arginine deiminase type-4
Molecular Weight
Mass (kDA):
74.415 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4 D3|4 72.34 cM |
| Sequence: | 4; |
Tissue Specificity
Expressed in pluripotent embryonic stem and induced pluripotent stem cells but not multipotent neural stem cells.
Diseases
- Rheumatoid Arthritis
- Arthritis
- Autoimmune Reaction
- Autoimmune Diseases
- Autoimmunity
- Neoplasms
- Lupus Erythematosus, Systemic
- Rheumatism
- Malignant Neoplasms
- Inflammation
- Dysequilibrium Syndrome
- Inflammatory Disorder
- Adenocarcinoma
Pathways
- Pathogenesis
- Immune Response
- Cell Death
- Cell Cycle
- Methylation
- Programmed Cell Death
- Cell Proliferation
- Localization
- Histone Arginine Methylation
- Cell Activation
- Histone Modification
- Cell Cycle Arrest
- Cell Differentiation
PTMs
- Citrullination
- Cleavage
- Methylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Padi4
bosterbio.com/bosterbio-gene-info-cards/Padi4
References
PMID: 10092850 by Rusd A.A., et al. Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.
PMID: 15087120 by Chavanas S., et al. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.