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ENPP1 Antibodies
AND ENPP1 ELISA kits, ENPP1 Proteins
Many biological assays use antibodies to detect ENPP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENPP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENPP1 antibodies...
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ENPP1 Infographic by Boster Bio
All ENPP1 Products
Product
Figures
Specificity
Applications
Price
Human
$250
Cat # PROTP22413
2ug, 10ug, 1mg
Cat # PROTP22413
2ug, 10ug, 1mg
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01342-1
100 μg/vial
Cat # A01342-1
100 μg/vial
ENPP1 Overview
Facts about Ectonucleotide pyrophosphatase/phosphodiesterase family member 1.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)
By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals.
Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates like GTP, CTP, TTP and UTP for their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | ENPP1 |
| Uniprot: | P22413 |
| Entrez: | 5167 |
Family
| Belongs to: |
|---|
| nucleotide pyrophosphatase/phosphodiesterase family |
Alternative Names
ectonucleotide pyrophosphatase/phosphodiesterase 1; E-NPP 1; ENPP1; ENPP-1; Ly-41 Antigen; M6S1; M6S1NPP1; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPP1; NPPS; NPPSalkaline phosphodiesterase 1; PC1; PC-1; PCA1; PCA1ARHR2; PDNP1; PDNP1ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1
Molecular Weight
Mass (kDA):
104.924 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q23.2 |
| Sequence: | 6; NC_000006.12 (131808020..131895155) |
Tissue Specificity
Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis.
Subcellular Localizations
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187). In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187).; [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted. Secreted following proteolytic cleavage.
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Obesity
- Calcinosis
- Arterial Calcification Of Infancy
- Vascular Calcification
- Cardiovascular Diseases
- Kidney Diseases
- Rickets
- Infarction
- Myocardial Infarction
Interacting Proteins
- INSR
Pathways
- Pathogenesis
- Bone Mineralization
- Secretion
- Ossification
- Insulin Secretion
- Transport
- Osteoblast Differentiation
- Bone Development
- Glucose Homeostasis
- Excretion
- Cell Adhesion
- Immune Response
- Cell Differentiation
PTMs
- Phosphorylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENPP1
bosterbio.com/bosterbio-gene-info-cards/ENPP1
References
PMID: 2211644 by Buckley M.F., et al. Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location.
PMID: 1315502 by Funakoshi I., et al. Molecular cloning of cDNAs for human fibroblast nucleotide pyrophosphatase.