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- Table of Contents
Facts about Pregnancy zone protein.
When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced).
Human | |
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Gene Name: | PZP |
Uniprot: | P20742 |
Entrez: | 5858 |
Belongs to: |
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protease inhibitor I39 (alpha-2-macroglobulin) family |
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; CPAMD6; Pregnancy Zone Protein; pregnancy-zone protein; PZP
Mass (kDA):
163.863 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (9140730..9208395, complement) |
Plasma. Prominent constituent of late- pregnancy sera.
Secreted.
PMID: 1989698 by Devriendt K., et al. Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction.
PMID: 7678727 by Thomsen N.K., et al. Alpha-macroglobulin domain structure studied by specific limited proteolysis.