Poliovirus receptor Antibodies

Poliovirus receptor (PVR)

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two distinct NK cell receptors: CD96 and CD226.

These interactions accumulates at the cell-cell contact site, leading to the creation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and trigger cytoxicity of activated NK cells.

Gene Information

Human
Gene Name:	PVR
Uniprot:	P15151
Entrez:	5817

Family

Belongs to:
nectin family

Alternative Names

CD155 antigen; CD155; HVED; NECL5; Necl-5; nectin-like 5; Nectin-like protein 5; poliovirus receptor; PVR; PVS; PVSFLJ25946; Tage4

Molecular Weight

Mass (kDA):
45.303 kDA

Genomic Context

Human
Location:	19q13.31
Sequence:	19; NC_000019.10 (44643798..44666162)

Subcellular Localizations

[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Secreted.; [Isoform Gamma]: Secreted.

Diseases

• Hypertensive Disease
• Pulmonary Hypertension
• Proliferative Vitreoretinopathy
• Retinal Detachment
• Pathologic Vasoconstriction
• Hypoxia
• Prostatic Hyperplasia
• Heart Failure
• Benign Prostatic Hypertrophy
• Hyperplasia
• Anoxia
• Cerebrovascular Accident
• Idiopathic Pulmonary Hypertension

• Retinal Diseases
• Stenosis
• Lower Urinary Tract Symptoms
• Hemorrhage
• Retinal Perforations
• Heart Diseases
• Rhegmatogenous Retinal Detachment

Interacting Proteins

• KRTAP10-7
• KRTAP10-8
• KRTAP10-9
• NOTCH2NL
• SLC30A2

• TIGIT

Pathways

• Vasoconstriction
• Vasodilation
• Pathogenesis
• Cell Proliferation
• Cell Migration
• Micturition
• Coagulation
• Transport
• Cell Adhesion
• Enucleation
• Localization
• Response To Hypoxia
• Wound Healing

• Reflex
• Secretion
• Cell Death
• Aging
• Oogenesis
• Complement Activation
• Translation

PTMs

• Phosphorylation
• Nitration
• Oxidation
• Glycosylation
• Methylation

• Demethylation
• Reduction
• Acetylation
• Deglycosylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PVR

Three of the Best Uses of the PVR Marker

The Poliovirus receptor (also known as PVR) is a cell adhesion molecule. Its sequence domain ranges from 21-343 aa. The PVR marker is versatile and can be utilized in SDS-PAGE as well other biochemical studies. This reagent is stable when stored at 2-8°C for up to one week. Additionally, it can be stored at temperatures ranging from -20degC to 80degC for storage over the long term. Avoid repeated freeze-thaw cycles to guarantee optimal storage. All scientists across the globe can participate in the Boster Bio program.

Poliovirus receptor

The Poliovirus receptor (also called CD155) is a transmembrane-specific protein encoded by the PVR gene. It is part of the immunoglobulin superfamily. The CD155 protein's transmembrane molecule mediates cell attachment to vitronectin. In addition, its intracellular domain is in contact and communicates with Tctex-1DYNLT1, light chains of dynein Tctex-1DYNLT1 along with Tctex-2. This gene is unique to the primate lineage, and has multiple transcript variants resulting in different isoforms. Boster Bio's antibodies against the Poliovirus receptor have been tested against positive and negative samples to ensure they work in the manner expected.

PVR cell adhesion molecule

The Boster Bio PVR cell adhesion protein targets a gene known as PVR cell adhesion molecule. This protein is overexpressed in human malignant tumors , and acts as a major immunoevasion factor which contributes to the growth of tumors and metastasis. The anti-PVR antibody offers several advantages for researchers. Anti-PVR antibodies provide specificity for immunogen, applications and specificity.

PVR gene

PVR plays a number of important roles in the immune system. It interacts with CD226 and TIGIT to stimulate the immune system. PVR is used in clinical trials to treat cancer by recruiting N cells and CD8+. PVR has many other functions that are still undiscovered. Further research is required to uncover them. Here are three of the greatest uses of the PVR gene.

Two transmembrane protein genes are encoded by the PVR gene both PVRa and PVRd. PVRa includes the entire first six exons, whereas PVRd employs an alternative splice site to incorporate additional nucleotides at the end of exon 6. Each encoded protein contains eight distinct amino acids. It also interacts with regulator proteins to enable distinct localizations in polarized cells.

The CD155 protein is encoded by the gene PVR. It is a transmembrane glyprotein from the immunoglobulins family. Its extracellular domain facilitates the cell's attachment to vitronectin while its intracellular domain interacts with the Tctex-1DYNLT1 light chain dynein. Its gene is highly conserved in primate specieslicati offersmultiple transcript variants resurimantsoull attaage,sp>

PVR geneer

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References

PMID: 2538245 by Mendelsohn C.L., et al. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily.

PMID: 2170108 by Koike S., et al. The poliovirus receptor protein is produced both as membrane-bound and secreted forms.