Peroxisomal biogenesis factor 19 (PEX19)

Necessary for premature peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs).

Binds and stabilizes newly synthesized PMPs from the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A in the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.